The use of quetiapine in the treatment of major depressive disorder: Evidence from clinical and experimental studies

被引:19
作者
Ignacio, Zuleide Maria [1 ,2 ]
Calixto, Ana Valquiria [1 ,3 ]
da Silva, Ritele Hernandez [2 ]
Quevedo, Joao [2 ,4 ,5 ,6 ]
Reus, Gislaine Zilli [2 ]
机构
[1] Fed Univ South Frontier UFFS, Lab Physiol Pharmacol & Psychopathol, Campus Chapeco, Chapeco, SC, Brazil
[2] Univ Southern Santa Catarina UNESC, Grad Program Hlth Sci, Lab Neurosci, Criciuma, SC, Brazil
[3] State Secretary Justice & Citizenship Santa Catar, Chapeco, SC, Brazil
[4] Univ Texas Hlth Sci Ctr Houston, Med Sch, Ctr Translat Psychiat, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
[5] Univ Texas Hlth Sci Ctr Houston, Med Sch, Ctr Excellence Mood Disorders, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
[6] Univ Texas Hlth Sci Ctr Houston, Grad Sch Biomed Sci, Neurosci Grad Program, Houston, TX 77030 USA
关键词
Quetiapine; Norquetiapine; Oxidative stress; Neuroinflammation; Epigenetic; Major depressive disorder; ANTIDEPRESSANT-LIKE BEHAVIOR; AMINOBUTYRIC-ACID LEVELS; CHRONIC MILD STRESS; ATYPICAL ANTIPSYCHOTICS; DOUBLE-BLIND; FUMARATE MONOTHERAPY; LIPID-PEROXIDATION; OXIDATIVE STRESS; BIPOLAR-I; 2ND-GENERATION ANTIPSYCHOTICS;
D O I
10.1016/j.neubiorev.2017.12.012
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Major depressive disorder (MDD) is a highly debilitating condition that is drawing considerable attention due to its high global prevalence and to the fact that treatments are still far from reaching the total number of patients affected. Among available treatment strategies, quetiapine is an important research target, due to antidepressant responses in patients resistant to classical treatments and in animals submitted to protocols that induce depressive -like behaviours. Quetiapine has a broad spectrum of action, within which are many mechanisms that seem to be related to the most effective antidepressant therapeutic responses. In this review, research results related to the pharmacokinetic profile, neurotransmitters, receptors and signalling molecular targets involved in the functional and structural plasticity of key brain regions in MDD are reported and discussed. Moreover, the physiological mechanisms, which are targets of quetiapine and are involved in both MDD and poor therapeutic response, are reported. The main adverse effects observed from therapeutic dosages and overdose are also described. Finally, the main mechanisms underlying the therapeutic response are highlighted.
引用
收藏
页码:36 / 50
页数:15
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