Lysosome-related organelles: unusual compartments become mainstream

被引：211

作者：

Marks, Michael S. ^{[1
,2
]}

Heijnen, Harry F. G. ^{[3
,4
,5
]}

Raposo, Graca ^{[6
,7
]}

机构：

[1] Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Perelman Sch Med, Dept Physiol, Philadelphia, PA 19104 USA

[3] Lab Clin Chem & Haematol, NL-3584 CX Utrecht, Netherlands

[4] Univ Med Ctr Utrecht, Dept Cell Biol, Cell Microscopy Ctr, NL-3584 CX Utrecht, Netherlands

[5] INSERM, UMR 949, EFS Alsace, F-67065 Strasbourg, France

[6] Inst Curie, Ctr Rech, F-75248 Paris 05, France

[7] CNRS, Unite Mixte Rech 144, F-75248 Paris 05, France

来源：

CURRENT OPINION IN CELL BIOLOGY | 2013年 / 25卷 / 04期

基金：

美国国家卫生研究院;

关键词：

HERMANSKY-PUDLAK-SYNDROME; WEIBEL-PALADE BODIES; SUSCEPTIBILITY FACTOR DYSBINDIN; NUCLEOTIDE EXCHANGE FACTOR; DENSE GRANULE BIOGENESIS; VON-WILLEBRAND-FACTOR; EARLY ENDOSOMES; IMMUNOLOGICAL SYNAPSE; ELECTRON TOMOGRAPHY; SECRETORY LYSOSOMES;

D O I：

10.1016/j.ceb.2013.04.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Lysosome-related organelles (LROs) comprise a group of cell type-specific subcellular compartments with unique composition, morphology and structure that share some features with endosomes and lysosomes and that function in varied processes such as pigmentation, hemostasis, lung plasticity and immunity. In recent years, studies of genetic diseases in which LRO functions are compromised have provided new insights into the mechanisms of LRO biogenesis and the regulated secretion of LRO contents. These insights have revealed previously unappreciated specialized endosomal sorting processes in all cell types, and are expanding our views of the plasticity of the endosomal and secretory systems in adapting to cell type-specific needs.

引用

页码：495 / 505

页数：11

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