Pd(II)-Catalyzed Enantioselective C-H Activation/C-O Bond Formation: Synthesis of Chiral Benzofuranones

被引：308

作者：

Cheng, Xiu-Fen ^{[1
]}

Li, Yan ^{[1
]}

Su, Yi-Ming ^{[1
]}

Yin, Feng ^{[1
]}

Wang, Jian-Yong ^{[1
]}

Sheng, Jie ^{[1
]}

Vora, Harit U. ^{[2
]}

Wang, Xi-Sheng ^{[1
]}

Yu, Jin-Quan ^{[2
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China

[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 04期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

NATURAL-PRODUCTS; PALLADIUM; FUNCTIONALIZATION; CYCLIZATION; C(SP(3))-H; AMINATION; COPPER; ACIDS; BENZOFURAN-2(3H)-ONES; DIBENZOFURANS;

D O I：

10.1021/ja311259x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pd(II)-catalyzed enantioselective C-H activation of phenylacetic acids followed by an intramolecular C-O bond formation afforded chiral benzofuranones. This reaction provides the first example of enantioselecctive C-H functionalizations through Pd(II)/Pd(IV) redox catalysis.

引用

页码：1236 / 1239

页数：4

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