Retinal Microenvironment in Dry Age-Related Macular Degeneration: A Mini-Review

被引：16
作者：
Barnett, Brad R. [1 ]
Handa, James T. [1 ]
机构：
[1] Johns Hopkins Sch Med, Wilmer Eye Inst, Baltimore, MD 21287 USA
来源：
GERONTOLOGY | 2013年 / 59卷 / 04期
关键词：
Aging; Age-related macular degeneration; Complement; Innate immunity; Oxidative stress; Oxidation-specific epitopes; COMPLEMENT FACTOR-H; PIGMENT EPITHELIUM; OXIDATIVE DAMAGE; RISK-FACTORS; GENE; POLYMORPHISM; VARIANT; NRF2; SUSCEPTIBILITY; ASSOCIATION;
D O I：
10.1159/000346169
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Background: Age-related macular degeneration (AMD) is the leading cause of blindness in the western world. To prevent what will certainly be a tremendous health and economic burden, effective therapeutics for AMD are urgently needed. To develop these agents in a timely fashion, the molecular pathways that cause disease progression must be elucidated. Objective:To briefly describe the clinical features of AMD, and review the current understanding of the molecular basis of AMD. Methods: A literature review. Results: The discussion will primarily focus on the interplay of oxidative stress and complement dysregulation and the resulting chronic proinflammatory state thought to be central in AMD pathogenesis. Conclusions: Oxidative stress and complement dysregulation play a substantive role in the development of AMD. Copyright (C) 2013 S. Karger AG, Basel
引用
收藏
页码：297 / 306
页数：10
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