Synthesis of dihydro-2H-pyran-3(4H)-one

被引：1
|
作者：
Mityuk, Andrey P. [1 ]
Denisenko, Aleksandr V. [1 ]
Grygorenko, Oleksandr O. [1 ,2 ]
Tolmachev, Andrey A. [1 ,2 ]
机构：
[1] Enamine Ltd, Alexandra Matrosova St 23, UA-01103 Kiev, Ukraine
[2] Kyiv Natl Taras Shevchenko Univ, UA-01601 Kiev, Ukraine
来源：
ARKIVOC | 2012年
关键词：
Oxygen compounds; heterocycles; cyclization; ketones; pyran; INHIBITORS; DISCOVERY; SERIES;
D O I：
10.3998/ark.5550190.0013.820
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A practical synthetic procedure for the synthesis of dihydro-2H-pyran-3(4H)-one is reported. The method commenced from the readily available alpha-ketoglutaric acid and allowed preparation of the title compound in four steps in 31% overall yield.
引用
收藏
页码：226 / 230
页数：5
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