A ring-closing metathesis pathway to fluorovinyl-containing nitrogen heterocyles

被引：41
作者：
De Matteis, V
van Delft, FL
Tiebes, J
Rutjes, FPJT
机构：
[1] Radboud Univ Nijmegen, Inst Mol & Mat, NL-6525 ED Nijmegen, Netherlands
[2] Bayer Crop Sci GmbH, D-65926 Frankfurt, Germany
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 2006卷 / 05期
关键词：
ring-closing metathesis; cyclic amino acids; vinyl fluoride; fluorinated heterocycles; fluoroacrylates;
D O I：
10.1002/ejoc.200500826
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of highly functionalized fluorinated piperidines is described. The key step in this synthesis is a ring-closing metathesis reaction involving fluoride-substituted olefins, which leads to the corresponding cyclic vinyl fluorides. Several sequences to arrive at differently substituted piperidines have been evaluated. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006).
引用
收藏
页码：1166 / 1176
页数：11
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