Highly sensitive electrochemiluminescent cytosensing using carbon nanodot@Ag hybrid material and graphene for dual signal amplification

被引:99
作者
Wu, Li [1 ,2 ]
Wang, Jiasi [1 ,2 ]
Ren, Jinsong [1 ]
Li, Wen [1 ,2 ]
Qu, Xiaogang [1 ]
机构
[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Lab Chem Biol,Div Biol Inorgan Chem, Changchun 130022, Jilin, Peoples R China
[2] Chinese Acad Sci, Changchun Inst Appl Chem, Grad Sch, Changchun 130022, Jilin, Peoples R China
关键词
ELECTROGENERATED CHEMILUMINESCENCE; DIAGNOSTICS;
D O I
10.1039/c3cc42637h
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Here we use functionalized carbon nanodots (C-dots) as novel electrochemiluminescence (ECL) probes and graphene nanosheets as signal amplification agents for highly sensitive and selective cancer cell detection. The ECL cytosensor shows superior cell-capture ability and exhibits a wide linear range and a low detection limit for cancer cells.
引用
收藏
页码:5675 / 5677
页数:3
相关论文
共 23 条
[1]   Oxidase-Like Activity of Polymer-Coated Cerium Oxide Nanoparticles [J].
Asati, Atul ;
Santra, Santimukul ;
Kaittanis, Charalambos ;
Nath, Sudip ;
Perez, J. Manuel .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (13) :2308-2312
[2]   Electrochemistry and electrogenerated chemiluminescence of CdTe nanoparticles [J].
Bae, Y ;
Myung, N ;
Bard, AJ .
NANO LETTERS, 2004, 4 (06) :1153-1161
[3]   Luminescent Carbon Nanodots: Emergent Nanolights [J].
Baker, Sheila N. ;
Baker, Gary A. .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (38) :6726-6744
[4]   Electrochemical and Electrochemiluminescence Determination of Cancer Cells Based on Aptamers and Magnetic Beads [J].
Ding, Caifeng ;
Ge, Ying ;
Zhang, Shusheng .
CHEMISTRY-A EUROPEAN JOURNAL, 2010, 16 (35) :10707-10714
[5]   Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: Applications in oral cancer [J].
El-Sayed, IH ;
Huang, XH ;
El-Sayed, MA .
NANO LETTERS, 2005, 5 (05) :829-834
[6]   New Horizons for Diagnostics and Therapeutic Applications of Graphene and Graphene Oxide [J].
Feng, Lingyan ;
Wu, Li ;
Qu, Xiaogang .
ADVANCED MATERIALS, 2013, 25 (02) :168-186
[7]   A graphene functionalized electrochemical aptasensor for selective label-free detection of cancer cells [J].
Feng, Lingyan ;
Chen, Yong ;
Ren, Jinsong ;
Qu, Xiaogang .
BIOMATERIALS, 2011, 32 (11) :2930-2937
[8]   Cytosensing and dynamic monitoring of cell surface carbohydrate expression by electrochemiluminescence of quantum dots [J].
Han, En ;
Ding, Lin ;
Lian, Hongzhen ;
Ju, Huangxian .
CHEMICAL COMMUNICATIONS, 2010, 46 (30) :5446-5448
[9]   Electrogenerated chemiluminescence of blue emitting ZnSe quantum dots and its biosensing for hydrogen peroxide [J].
Hu, Xiaofeng ;
Han, Heyou ;
Hua, Lijuan ;
Sheng, Zonghai .
BIOSENSORS & BIOELECTRONICS, 2010, 25 (07) :1843-1846
[10]   Multifunctional Oval-Shaped Gold-Nanoparticle-Based Selective Detection of Breast Cancer Cells Using Simple Colorimetric and Highly Sensitive Two-Photon Scattering Assay [J].
Lu, Wentong ;
Arumugam, Ranjini ;
Senapati, Dulal ;
Singh, Anant K. ;
Arbneshi, Tahir ;
Khan, Sadia Afrin ;
Yu, Hongtao ;
Ray, Paresh Chandra .
ACS NANO, 2010, 4 (03) :1739-1749