Dietary whey supplementation in experimental models of wound healing

被引：14

作者：

Ogunc, Ayliz Velioglu ^{[1
,2
]}

Manukyan, Manuk ^{[3
]}

Cingi, Asim ^{[3
]}

Eksioglu-Demiralp, Emel ^{[4
]}

Aktan, A. Odemir ^{[3
]}

Yalcin, A. Suha ^{[1
]}

机构：

[1] Marmara Univ, Sch Med, Dept Biochem, TR-34668 Istanbul, Turkey

[2] Marmara Univ, Vocat Sch Hlth Related Profess, TR-34668 Istanbul, Turkey

[3] Marmara Univ, Dept Gen Surg, TR-34668 Istanbul, Turkey

[4] Marmara Univ, Sch Med, Dept Hematol & Immunol, TR-34668 Istanbul, Turkey

来源：

INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH | 2008年 / 78卷 / 02期

关键词：

anastomosis; glutathione; lipid peroxidation; whey; wound healing;

D O I：

10.1024/0300-9831.78.2.70

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Whey is a dairy product containing milk serum proteins with diverse biological effects. In this study, the effect of dietary whey supplementation on wound healing was investigated. Rats were fed a standard or whey-supplemented diet for three weeks. Wound healing parameters, glutathione, and lipid peroxide levels were determined three days after the application of two different models of wound healing, i.e. laparotomy and colonic anastomosis. Dietary whey supplementation significantly increased glutathione levels and suppressed lipid peroxidation after experimental laparotomy and colonic anastomosis. Bursting pressures, hydroxyproline, and cytokine levels were not changed. Our results show that dietary whey supplementation increases glutathione synthesis and cellular antioxidant defense. Long-term effects of whey feeding on wound healing remains to be investigated.

引用

页码：70 / 73

页数：4

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