Intracellularly Degradable, Self-Assembled Amphiphilic Block Copolycurcumin Nanoparticles for Efficient In Vivo Cancer Chemotherapy

被引：32

作者：

Lv, Li ^{[1
]}

Guo, Yuan ^{[2
,3
]}

Shen, Yuanyuan ^{[1
]}

Liu, Jieying ^{[1
]}

Zhang, Wenjun ^{[1
]}

Zhou, Dejian ^{[2
,3
]}

Guo, Shengrong ^{[1
,2
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China

[2] Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England

[3] Univ Leeds, Astbury Ctr Struct Mol Biol, Leeds LS2 9JT, W Yorkshire, England

来源：

ADVANCED HEALTHCARE MATERIALS | 2015年 / 4卷 / 10期

基金：

英国工程与自然科学研究理事会; 中国国家自然科学基金;

关键词：

MULTIDRUG-RESISTANT CANCER; DRUG-DELIVERY; PHASE-I; CURCUMIN; CELLS; PACLITAXEL; PLATFORM; THERAPY; RELEASE; CONJUGATE;

D O I：

10.1002/adhm.201500075

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Intracellularly degradable, self-assembled amphiphilic biotin-poly(ethylene glycol)-b-poly(curcumin-dithiodipropionic acid) nanoparticles are developed. They display excellent in vivo anticancer efficacy, benefitted from their high tumor-targeted accumulation and stimuli-triggered intracellular drug release. They can be loaded with other anticancer drugs (e.g., doxorubicin) to exploit the synergy of combinational dual-drug therapy to further enhance in vivo anticancer efficacy. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1496 / 1501

页数：6

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