Intracellularly Degradable, Self-Assembled Amphiphilic Block Copolycurcumin Nanoparticles for Efficient In Vivo Cancer Chemotherapy

被引：32
|
作者：
Lv, Li [1 ]
Guo, Yuan [2 ,3 ]
Shen, Yuanyuan [1 ]
Liu, Jieying [1 ]
Zhang, Wenjun [1 ]
Zhou, Dejian [2 ,3 ]
Guo, Shengrong [1 ,2 ,3 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China
[2] Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England
[3] Univ Leeds, Astbury Ctr Struct Mol Biol, Leeds LS2 9JT, W Yorkshire, England
来源：
ADVANCED HEALTHCARE MATERIALS | 2015年 / 4卷 / 10期
基金：
英国工程与自然科学研究理事会; 中国国家自然科学基金;
关键词：
MULTIDRUG-RESISTANT CANCER; DRUG-DELIVERY; PHASE-I; CURCUMIN; CELLS; PACLITAXEL; PLATFORM; THERAPY; RELEASE; CONJUGATE;
D O I：
10.1002/adhm.201500075
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Intracellularly degradable, self-assembled amphiphilic biotin-poly(ethylene glycol)-b-poly(curcumin-dithiodipropionic acid) nanoparticles are developed. They display excellent in vivo anticancer efficacy, benefitted from their high tumor-targeted accumulation and stimuli-triggered intracellular drug release. They can be loaded with other anticancer drugs (e.g., doxorubicin) to exploit the synergy of combinational dual-drug therapy to further enhance in vivo anticancer efficacy. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：1496 / 1501
页数：6
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