Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross-Sectional Analysis in a Population at High Cardiovascular Risk

被引：7

作者：

Rubin-Garcia, Maria ^{[1
]}

Vitelli-Storelli, Facundo ^{[1
]}

Alvarez-Alvarez, Laura ^{[1
]}

Martinez-Gonzalez, Miguel Angel ^{[2
,3
,4
]}

Salas-Salvado, Jordi ^{[3
,5
,6
,7
]}

Corella, Dolores ^{[3
,8
]}

Hernaez, Alvaro ^{[3
,9
,10
]}

Martinez, J. Alfredo ^{[3
,11
,12
]}

Alonso-Gomez, Angel M. ^{[3
,13
]}

Warnberg, Julia ^{[3
,14
,15
]}

Vioque, Jesus ^{[16
,17
]}

Romaguera, Dora ^{[3
,18
]}

Lopez-Miranda, Jose ^{[3
,19
]}

Estruch, Ramon ^{[3
,20
,21
]}

Tinahones, Francisco J. ^{[3
,15
,22
]}

Serra-Majem, Luis, I ^{[3
,23
,24
]}

Cano-Ibanez, Naomi ^{[25
]}

Tur, Josep A. ^{[3
,18
,26
]}

Marcos-Delgado, Alba ^{[1
]}

Tresserra-Rimbau, Anna ^{[3
,27
]}

Pinto, Xavier ^{[3
,28
]}

Delgado-Rodriguez, Miguel ^{[11
,29
]}

Matia-Martin, Pilar ^{[30
]}

Vidal, Josep ^{[31
,32
]}

Vazquez, Clotilde ^{[3
,33
]}

Daimiel, Lidia ^{[34
]}

Ros, Emili ^{[3
,35
]}

Vazquez-Ruiz, Zenaida ^{[2
,3
]}

Babio, Nancy ^{[3
,5
,6
,7
]}

Barragan, Rocio ^{[3
,8
]}

Castaner-Nino, Olga ^{[12
]}

Razquin, Cristina ^{[2
,3
]}

Tojal-Sierra, Lucas ^{[3
,13
]}

Gomez-Gracia, Enrique ^{[15
,36
]}

Gonzalez-Palacios, Sandra ^{[16
,17
]}

Morey, Marga ^{[3
,18
]}

Garcia-Rios, Antonio ^{[3
,19
]}

Castro-Barquero, Sara ^{[3
,20
,21
]}

Bernal-Lopez, Maria Rosa ^{[3
,15
,37
]}

Santos-Lozano, Jose Manuel ^{[3
,23
,24
]}

Ruiz-Canela, Miguel ^{[2
,3
]}

Castro-Salomo, Antoni ^{[6
,7
]}

Pascual-Castello, Eva Cristina ^{[8
]}

Moldon, Veronica ^{[12
]}

Bullon-Vela, Vanessa ^{[2
]}

Sorto-Sanchez, Carolina ^{[3
,13
]}

Cenoz-Osinaga, Juan Carlos ^{[2
]}

Gutierrez, Liliana ^{[6
,7
]}

Mengual, Maira ^{[12
]}

Lamuela-Raventos, Rosa Maria ^{[3
,28
]}

机构：

[1] Univ Leon, Grp Invest Interact Gene Environm & Hlth GIIGAS, Inst Biomed IBIOMED, Leon, Spain

[2] Univ Navarra, Dept Prevent Med & Publ Hlth, Navarra Inst Hlth Res IdiSNA, Pamplona, Spain

[3] Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain

[4] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA

[5] Univ Rovira & Virgili, Unitat Nutr Humana, Dept Bioquim & Biotecnol, Reus, Spain

[6] Univ Hosp St Joan Reus, Unitat Nutr, Serv Med Interna, Reus, Spain

[7] Inst Invest Sanitaria Pere Virgili IISPV, Reus, Spain

[8] Univ Valencia, Dept Prevent Med, Valencia, Spain

[9] Inst Hosp del Mar Invest Med IMIM, Cardiovasc Risk & Nutr Res Grp, Barcelona, Spain

[10] Norwegian Inst Publ Hlth, Ctr Fertil & Hlth, Oslo, Norway

[11] Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona, Spain

[12] CEI UAM CSIC, Precis Nutr Programme, IMDEA Food, Madrid, Spain

[13] Univ Basque Country UPV EHU, Araba Univ Hosp, Bioaraba Hlth Res Inst, Osakidetza Basque Hlth Serv, Vitoria, Spain

[14] Univ Malaga, Dept Nursing, Sch Hlth Sci, Malaga, Spain

[15] Inst Invest Biomed Malaga IBIMA, Malaga, Spain

[16] Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain

[17] Univ Miguel Hernandez ISABIAL UMH, Inst Invest Sanitaria & Biomed Alicante, Alicante, Spain

[18] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca, Spain

[19] Univ Cordoba, Maimonides Biomed Res Inst Cordoba IMIBIC, Dept Internal Med, Reina Sofia Univ Hosp, Cordoba, Spain

[20] Univ Barcelona, Dept Med, Fac Med & Life Sci, Barcelona, Spain

[21] Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain

[22] Virgen de la Victoria Hosp, Dept Endocrinol, Malaga, Spain

[23] Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci IUIBS, Las Palmas Gran Canaria, Spain

[24] Ctr Hosp Univ Insular Matemo Infantil CHUIMI, Canarian Hlth Serv, Las Palmas Gran Canaria, Spain

[25] Univ Granada, Dept Prevent Med & Publ Hlth, Complejo Hosp Univ Granada, Inst Invest Biosanitaria IbsGRANADA, Granada, Spain

[26] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain

[27] Univ Barcelona, Sch Pharm & Food Sci, Dept Nutr Food Sci & Gastron, INSA,XIA, Barcelona, Spain

[28] Hosp Univ Bellvitge, Internal Med, Lipids & Vasc Risk Unit, Barcelona, Spain

[29] Univ Jaen, Div Prevent Med, Fac Med, Jaen, Spain

[30] Inst Invest Sanitaria Hosp Clin San Carlos IdISSC, Dept Endocrinol & Nutr, Madrid, Spain

[31] Inst Salud Carlos III ISCIII, CIBER Diabet & Enfermedades Metab CIBERDEM, Madrid, Spain

[32] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol, Barcelona, Spain

[33] Univ Autonoma, Dept Endocrinol & Nutr, Inst Invest Biomed IISFJD, Hosp Fdn Jimenez Diaz, Madrid, Spain

[34] IMDEA Food CEI UAM CSIC, Precis Nutr & Obes Program, Nutr Control Epigenome Grp, Madrid, Spain

[35] Hosp Clin Barcelona, Dept Endocrinol & Nutr, Lipid Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Barcelona, Spain

[36] Univ Malaga, Dept Prevent Med & Publ Hlth, Sch Med, Malaga, Spain

[37] Reg Univ Hosp MalagaSpain, Dept Internal Med, Malaga, Spain

来源：

JOURNAL OF THE AMERICAN HEART ASSOCIATION | 2022年 / 11卷 / 20期

基金：

欧盟地平线“2020”; 欧洲研究理事会;

关键词：

hyperuricemia; polyphenols; uric acid; FOOD-FREQUENCY QUESTIONNAIRE; INVERSE ASSOCIATION; COFFEE CONSUMPTION; MEDITERRANEAN DIET; METABOLIC SYNDROME; HEALTH; GOUT; VALIDATION; FLAVONOIDS; MECHANISM;

D O I：

10.1161/JAHA.122.026053

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess the association of the intake of different classes of polyphenols with serum uric acid and hyperuricemia. Methods and Results This cross-sectional analysis involved baseline data of 6332 participants. Food polyphenol content was estimated by a validated semiquantitative food frequency questionnaire and from the Phenol-Explorer database. Multivariable-adjusted linear regression models with serum uric acid (milligrams per deciliter) as the outcome and polyphenol intake (quintiles) as the main independent variable were fitted. Cox regression models with constant follow-up time (t=1) were performed to estimate the prevalence ratios (PRs) of hyperuricemia (>= 7 mg/dL in men and >= 6 mg/dL in women). An inverse association between the intake of the phenolic acid class (beta coefficient, -0.17 mg/dL for quintile 5 versus quintile 1 [95% CI, -0.27 to -0.06]) and hydroxycinnamic acids (beta coefficient, -0.19 [95% CI, -0.3 to -0.09]), alkylmethoxyphenols (beta coefficient, -0.2 [95% CI, -0.31 to -0.1]), and methoxyphenols (beta coefficient, -0.24 [95% CI, -0.34 to -0.13]) subclasses with serum uric acid levels and hyperuricemia (PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.80 [95% CI, 0.70-0.92]; and PR, 0.79 [95% CI, 0.69-0.91]; respectively) was found. The intake of hydroxybenzoic acids was directly and significantly associated with mean serum uric acid levels (beta coefficient, 0.14 for quintile 5 versus quintile 1 [95% CI, 0.02-0.26]) but not with hyperuricemia. Conclusions In individuals with metabolic syndrome, a higher intake of some polyphenol subclasses (hydroxycinnamic acids, alkylmethoxyphenol, and methoxyphenol) was inversely associated with serum uric acid levels and hyperuricemia. Nevertheless, our findings warrant further research.

引用

页数：28

共 62 条

[21] Antihyperuricemic effect of dietary polyphenol sinapic acid commonly present in various edible food plants [J].