Pharmacotherapy for Pulmonary Hypertension

被引：16

作者：

Steinhorn, Robin H. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Pediat, Ann & Robert H Lurie Childrens Hosp Chicago, Chicago, IL 60611 USA

来源：

PEDIATRIC CLINICS OF NORTH AMERICA | 2012年 / 59卷 / 05期

关键词：

Pulmonary hypertension; Pulmonary vasculature; Vasodilator; Nitric oxide; Phosphodiesterase; Prostacyclin; Endothelin; INHALED NITRIC-OXIDE; ENDOTHELIN RECEPTOR ANTAGONISTS; RANDOMIZED CONTROLLED-TRIAL; CONGENITAL HEART-SURGERY; TERM NEWBORN-INFANTS; ARTERIAL-HYPERTENSION; INTRAVENOUS EPOPROSTENOL; PRETERM INFANTS; DOUBLE-BLIND; BRONCHOPULMONARY DYSPLASIA;

D O I：

10.1016/j.pcl.2012.07.011

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Pulmonary arterial hypertension is a serious disease with significant morbidity and mortality. Although it can occur idiopathically, it is more commonly associated with other cardiac or lung diseases. While most of the available therapies have been tested in adult populations and most therapies in children remain off-label, new reports and randomized trials are emerging that inform the treatment of pediatric populations. This review discusses currently available therapies for pediatric pulmonary hypertension, their biological rationales, and evidence for their clinical effectiveness.

引用

页码：1129 / +

页数：19

共 123 条

[1] Recent progress in understanding pediatric pulmonary hypertension
Abman, Steven H.
Ivy, D. Dunbar
[J]. CURRENT OPINION IN PEDIATRICS, 2011, 23 (03) : 298 - 304
[2] Role of Endothelin Receptor Antagonists in the Treatment of Pulmonary Arterial Hypertension
Abman, Steven H.
[J]. ANNUAL REVIEW OF MEDICINE, 2009, 60 : 13 - 23
[3] Pulmonary NO synthase expression is attenuated in a fetal baboon model of chronic lung disease
Afshar, S
Gibson, LL
Yuhanna, IS
Sherman, TS
Kerecman, JD
Grubb, PH
Yoder, BA
McCurnin, DC
Shaul, PW
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2003, 284 (05) : L749 - L758
[4] An Hyo Soon, 2010, Korean Circ J, V40, P131, DOI 10.4070/kcj.2010.40.3.131
[5] L-Citrulline ameliorates chronic hypoxia-induced pulmonary hypertension in newborn piglets
Ananthakrishnan, Madhumita
Barr, Frederick E.
Summar, Marshall L.
Smith, Heidi A.
Kaplowitz, Mark
Cunningham, Gary
Magarik, Jordan
Zhang, Yongmei
Fike, Candice D.
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2009, 297 (03) : L506 - L511
[6] Combined effects of nitric oxide and oxygen during acute pulmonary vasodilator testing
Atz, AM
Adatia, I
Lock, JE
Wessel, DL
[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1999, 33 (03) : 813 - 819
[7] Sildenafil ameliorates effects of inhaled nitric oxide withdrawal
Atz, AM
Wessel, DL
[J]. ANESTHESIOLOGY, 1999, 91 (01) : 307 - 310
[8] Inhaled nitric oxide in preterm infants undergoing mechanical ventilation
Ballard, Roberta A.
Truog, William E.
Cnaan, Avital
Martin, Richard J.
Ballard, Philip L.
Merrill, Jeffrey D.
Walsh, Michele C.
Durand, David J.
Mayock, Dennis E.
Eichenwald, Eric C.
Null, Donald R.
Hudak, Mark L.
Puri, Asha R.
Golombek, Sergio G.
Courtney, Sherry E.
Stewart, Dan L.
Welty, Stephen E.
Phibbs, Roderic H.
Hibbs, Anna Maria
Luan, Xianqun
Wadlinger, Sandra R.
Asselin, Jeanette M.
Coburn, Christine E.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (04) : 343 - 353
[9] Oral sildenafil in infants with persistent pulmonary hypertension of the newborn: A pilot randomized blinded study
Baquero, H
Soliz, A
Neira, F
Venegas, ME
Sola, A
[J]. PEDIATRICS, 2006, 117 (04) : 1077 - 1083
[10] Pharmacokinetics and safety of intravenously administered citrulline in children undergoing congenital heart surgery: Potential therapy for postoperative pulmonary hypertension
Barr, Frederick E.
Tirona, Rommel G.
Taylor, Mary B.
Rice, Geraldine
Arnold, Judith
Cunningham, Gary
Smith, Heidi A. B.
Campbell, Adam
Canter, Jeffrey A.
Christian, Karla G.
Drinkwater, Davis C.
Scholl, Frank
Kavanaugh-McHugh, Ann
Summar, Marshall L.
[J]. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2007, 134 (02) : 319 - 326

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