A novel and convenient copper-catalyzed three-component coupling of aldehydes, alkynes, and hydroxylamines leading to propargylamines

被引：11

作者：

Guo, Na ^{[1
,2
]}

Ji, Jian-Xin ^{[1
]}

机构：

[1] Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China

[2] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 36期

基金：

中国国家自然科学基金;

关键词：

Copper catalysis; Three-component; Aldehyde; Alkyne; Hydroxylamine; Propargylamine; C-H ACTIVATION; HIGHLY ENANTIOSELECTIVE SYNTHESIS; ONE-POT SYNTHESIS; SECONDARY-AMINES; EFFICIENT; SILVER; COMPLEX; WATER; GOLD; CYCLIZATION;

D O I：

10.1016/j.tetlet.2012.03.009

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first copper-catalyzed direct three-component coupling reaction of aldehydes, alkynes, and hydroxylamines for the synthesis of propargylamines has been developed under mild conditions, which has the advantages of ready availability of catalyst as well as operation simplicity. The present protocol provides an appealing alternative for the construction of propargylamines in a simple and one-pot procedure. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：4797 / 4801

页数：5

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