A new sesquiterpene lactone from Hosta ensata

被引：8
作者：
Liu, Hong-xin [1 ,2 ]
Sun, Qian-yun [3 ,4 ]
Yang, Fu-mei [3 ,4 ]
Zhao, Fu-wei [1 ,2 ]
Wang, Yue-hu [1 ]
Long, Chun-lin [1 ,5 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650204, Peoples R China
[2] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
[3] Key Lab Chem Nat Prod, Guiyang 550002, Guizhou Provinc, Peoples R China
[4] Chinese Acad Sci, Guiyang 550002, Peoples R China
[5] Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2012年 / 48卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Liliaceae; Hosta ensata; sesquiterpene; hostasolide A; COLORIMETRIC ASSAY; ACID;
D O I：
10.1007/s10600-012-0316-z
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new monocyclofarnesane-type sesquiterpenoid, hostasolide A (1), along with five known compounds, lyciumide A, feruloyltyramine, dimethyl 4,4'-dihydroxy-3,3'-dimethoxy-beta-truxinate, 4-hydroxy3-methoxybenzaldehyde, and 3,4-dimethoxycinnamic acid, were isolated from the whole plant of Hosta ensata. The structure of compound 1 was determined on the basis of spectroscopic analysis. The inhibitory activities of compound 1 against acetylcholinesterase, human chronic myelogenous leukemia K562 cells, and human breast cancer MCF-7 cells were also evaluated.
引用
收藏
页码：580 / 582
页数：3
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