Cytotoxic triterpenoids from the stem bark ofAglaia angustifolia

被引：6
|
作者：
Hutagaol, Ricson Pemimpin [1 ,2 ]
Harneti, Desi [1 ]
Safari, Agus [1 ]
Hidayat, Ace Tatang [1 ,3 ]
Supratman, Unang [1 ,3 ]
Awang, Khalijah [4 ]
Shiono, Yoshihito [5 ]
机构：
[1] Univ Padjadjaran, Fac Math & Nat Sci, Dept Chem, Jl Raya Bandung Sumedang Km 21, Jatinangor 45363, Indonesia
[2] Univ Nusa Bangsa, Fac Math & Nat Sci, Dept Chem, Jl Sholeh Iskandar Km 4, Bogor 16166, Indonesia
[3] Univ Padjadjaran, Cent Lab, Jatinangor 45363, Indonesia
[4] Univ Malaya, Fac Sci, Dept Chem, Kuala Lumpur 59100, Malaysia
[5] Yamagata Univ, Fac Agr, Dept Food Life & Environm Sci, Yamagata 9978555, Japan
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2021年 / 23卷 / 08期
关键词：
Aglaia angustifolia; angustifolianin; MCF-7; Meliaceae; seco-apotirucallane; AGLAIA; PROTOLIMONOIDS; CONSTITUENTS; DERIVATIVES;
D O I：
10.1080/10286020.2020.1776704
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A seco-apotirucallane-type triterpenoid, namely angustifolianin (1), along with three dammarane-type triterpenoids, (20S, 24S)-epoxy-dammarane-3 beta,25-diol (2), 3-epi-cabraleahydroxylactone (3), and cabralealactone (4), were isolated from the stem bark ofAglaia angustifoliaMiq. The Chemical structure of the new compounds was elucidated on the basis of spectroscopic data. All of the compounds were evaluated for their cytotoxic effects against MCF-7 breast cancer cells. Among those compounds, angustifolianin (1)showed strongest cytotoxic activity with an IC(50)value of 50.5 mu g/ml.
引用
收藏
页码：781 / 788
页数：8
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