Early exercise in spinal cord injured rats induces allodynia through TrkB signaling

被引：30
作者：
Endo, Teruaki [2 ]
Ajiki, Takashi [2 ]
Inoue, Hirokazu [2 ]
Kikuchi, Motoshi [3 ]
Yashiro, Takashi [3 ]
Nakama, Sueo [2 ]
Hoshino, Yuichi [2 ]
Murakami, Takashi [1 ]
Kobayashi, Eiji [1 ]
机构：
[1] Jichi Med Univ, Div Organ Replacement Res, Ctr Mol Med, Shimotsuke, Tochigi 3290498, Japan
[2] Jichi Med Univ, Dept Orthoped Surg, Shimotsuke, Tochigi 3290498, Japan
[3] Jichi Med Univ, Dept Anat, Div Histol, Shimotsuke, Tochigi 3290498, Japan
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 381卷 / 03期
关键词：
Spinal cord injury; Assisted stepping exercise; Neuronal regeneration; Neuropathic pain; Allodynia; Brain-derived neurotrophic factor; Tropomyosin-related kinase B; NEUROTROPHIC FACTOR; RECEPTOR; GROWTH;
D O I：
10.1016/j.bbrc.2009.02.043
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Rehabilitation is important for the functional recovery of patients with spinal cord injury. However, neurological events associated with rehabilitation remain unclear, Herein, we investigated neuronal regeneration and exercise following spinal cord injury, and found that assisted stepping exercise of spinal cord injured rats in the inflammatory phase causes allodynia, Sprague-Dawley rats with thoracic spinal cord contusion injury were Subjected to assisted stepping exercise 7 clays following injury. Exercise promoted microscopic recovery of corticospinal tract neurons, but the paw withdrawal threshold decreased and C fibers had aberrantly sprouted, suggesting a potential cause of the allodynia. Tropomyosin-related kinase B (TrkB) receptor for brain-derived neurotrophic factor (BDNF) was expressed on aberrantly sprouted C-fibers. Blocking of BDNF-TrkB signaling markedly suppressed aberrant sprouting and decreased the paw withdrawal threshold. Thus, early rehabilitation for spinal cord injury may cause allodynia with aberrant Sprouting of C-fibers through BDNF-TrkB signaling. (C) 2009 Elsevier Inc. All rights reserved.
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收藏
页码：339 / 344
页数：6
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