Stimuli-Responsive DNA-Functionalized Nano-/Microcontainers for Switchable and Controlled Release

被引：158

作者：

Lu, Chun-Hua ^{[1
]}

Willner, Itamar ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Inst Chem, IL-91904 Jerusalem, Israel

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 42期

基金：

欧洲研究理事会;

关键词：

lipid-DNA micelles; mesoporous nanoparticles; microcapsules; nanomedicine; vesicles; MESOPOROUS SILICA NANOPARTICLES; BLOCK-COPOLYMER MICELLES; NUCLEIC-ACID NANOSTRUCTURES; REMOTE-CONTROLLED RELEASE; BY-LAYER CAPSULES; DRUG-DELIVERY; IN-VITRO; MOLECULAR-BEACON; QUADRUPLEX DNA; LOGIC GATES;

D O I：

10.1002/anie.201503054

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Stimuli-responsive DNA-functionalized nano-and microcontainers composed of mesoporous SiO2 nanoparticles (MP SiO2 NPs), microcapsules, or micelles/vesicles act as carriers for the transport and release of drugs. The information encoded in the DNA sequences provides instructive information for the gating of drug-loaded pores of MP SiO2 NPs, for the assembly and degradation of microcapsules or lipid-DNA micelles/vesicles, and for the targeting of nano-/microcontainers to cancer cells. Different triggers are applied to release the drugs loaded in the nano-/microcontainers by unlocking the pores of the MP SiO2 NPs or by degradation of the containers. These include the use of switchable DNA nanostructures (nucleic acid hairpins, i-motif, G-quadruplexes) and the implementation of chemical, thermal, or photonic stimuli. Also, catalytic processes stimulated by DNAzymes or enzymes are used to release drugs from the nano-/microcontainers.

引用

页码：12212 / 12235

页数：24

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