Regulation of chromatin structure via histone post-translational modification and the link to carcinogenesis

被引：47

作者：

Thompson, Laura L. ^{[1
,2
]}

Guppy, Brent J. ^{[1
,2
]}

Sawchuk, Laryssa ^{[1
,2
]}

Davie, James R. ^{[1
,2
,3
]}

McManus, Kirk J. ^{[1
,2
]}

机构：

[1] Univ Manitoba, Dept Biochem & Med Genet, Winnipeg, MB, Canada

[2] CancerCare Manitoba, Manitoba Inst Cell Biol, Winnipeg, MB R3E 0V9, Canada

[3] John Buhler Res Ctr, Manitoba Inst Child Hlth, Winnipeg, MB R3E 3P4, Canada

来源：

CANCER AND METASTASIS REVIEWS | 2013年 / 32卷 / 3-4期

基金：

加拿大健康研究院;

关键词：

Histones; Post-translational modifications; Phosphorylation; Methylation; Ubiquitination; Epigenetics; Genome instability; Cancer; AURORA-B KINASE; STRESS-ACTIVATED PROTEIN-KINASE-1; NUCLEOSOME CORE PARTICLE; H3; PHOSPHORYLATION; CELL-CYCLE; MITOTIC PHOSPHORYLATION; GENE-EXPRESSION; H4; LYS-20; HOMOLOGOUS RECOMBINATION; GENOMIC INSTABILITY;

D O I：

10.1007/s10555-013-9434-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The loss of genome integrity contributes to the development of tumors. Although genome instability is associated with virtually all tumor types including both solid and liquid tumors, the aberrant molecular origins that drive this instability are poorly understood. It is now becoming clear that epigenetics and specific histone post-translational modifications (PTMs) have essential roles in maintaining genome stability under normal conditions. A strong relationship exists between aberrant histone PTMs, genome instability, and tumorigenesis. Changes in the genomic location of specific histone PTMs or alterations in the steady-state levels of the PTM are the consequence of imbalances in the enzymes and their activities catalyzing the addition of PTMs ("writers") or removal of PTMs ("erasers"). This review focuses on the misregulation of three specific types of histone PTMs: histone H3 phosphorylation at serines 10 and 28, H4 mono-methylation at lysine 20, and H2B ubiquitination at lysine 120. We discuss the normal regulation of these PTMs by the respective "writers" and "erasers" and the impact of their misregulation on genome stability.

引用

页码：363 / 376

页数：14

共 123 条

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