Saponification to improve the antioxidant activity of astaxanthin extracts from Penaeus sinensis (Solenocera crassicornis) by-products and intervention effect on Paracetamol-induced acute hepatic injury in rat

被引：11
作者：
Song, Ru [1 ]
Jia, Zhe [1 ]
Xu, Yan [1 ]
Zhang, Xiaoxia [1 ]
Wei, Rongbian [2 ]
Sun, Jipeng [3 ]
机构：
[1] Zhejiang Ocean Univ, Sch Food Sci & Pharm, Zhoushan 316022, Peoples R China
[2] Zhejiang Ocean Univ, Sch Marine Sci & Technol, Zhoushan 316022, Peoples R China
[3] Zhejiang Marine Dev Res Inst, Res Off Marine Biol Resources Utilizat & Dev, Zhoushan 316021, Peoples R China
来源：
JOURNAL OF FUNCTIONAL FOODS | 2020年 / 73卷
基金：
国家重点研发计划;
关键词：
Penaeus sinensis by-products; Astaxanthin extract; Saponification; Antioxidant activity; Paracetamol; Acute hepatic injury; OXIDATIVE STRESS; TRANS-ASTAXANTHIN; IN-VITRO; INDUCED HEPATOTOXICITY; ANTIAGING ACTIVITIES; NRF2; LIVER; ISOMERS; PATHWAY; DAMAGE;
D O I：
10.1016/j.jff.2020.104150
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Astaxanthin (Asta) extracts from Penaeus sinensis by-products showed increased in vitro antioxidant activity after saponification as compared to the non-saponification Asta. The increases of geometrical Asta (activity order of 9-cis > 13-cis > all-trans) and Asta stereoisomers could be responsible for the improved antioxidant activities of saponification Asta. Non-saponification or saponification Asta (150 mg/kg) was administered in Sprague-Dawley rats via gavage daily for 14 days before paracetamol (PCM)-induced (400 mg/kg) acute hepatotoxicity. Pre-treatment with non-saponification or saponification Asta counterbalanced rats liver oxidative stress by PCM-induction through restoring reduced glutathione content, total superoxide dismutase and glutathione peroxidase activities. Moreover, Asta pre-treatment decreased glutathione-S-transferase-P (placental form) foci, p53 and p38 expressions as compared to the model group. Pre-treated with Asta up-modulated phase-II enzyme NAD(P)H: quinine oxidoreductase-1 or Hemoxygenase-1 expressions, indicating the nuclear erythroid 2-related factor 2-antioxidant response element (Nrf2-ARE) pathway for the non-saponification or saponification Asta to alleviate PCM-induced hepatotoxicity in rats.
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页数：12
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