Targeted Drug Delivery in Cancer Cells with Red-Light Photoactivated Mesoporous Silica Nanoparticles

被引：158

作者：

Mackowiak, Stephan A.

Schmidt, Alexandra

Weiss, Veronika

Argyo, Christian

von Schirnding, Constantin

Bein, Thomas ^{[1
]}

Braeuchle, Christoph

机构：

[1] Univ Munich LMU, Dept Chem, D-81377 Munich, Germany

来源：

NANO LETTERS | 2013年 / 13卷 / 06期

关键词：

Mesoporous silica nanoparticles; nanoparticle drug delivery; targeting cancer cells; folic acid; epidermal growth factor; photosensitizer; SUPPORTED LIPID-BILAYERS; GENE DELIVERY; DENDRIMERS; RELEASE; PHOTOSENSITIZER; POLYMERS; VIRUSES; DESIGN; RNA;

D O I：

10.1021/nl400681f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mesoporous nanoparticles for drug delivery would benefit significantly from further improvements in targeting efficiency and endosomal release. We present a system based on colloidal mesoporous silica nanoparticles with targeting-ligands and a red-light photosensitizer. This nanoparticle system provides spatial and temporal control of the release of drugs into the cytosol of cancer cells. Furthermore, the system presents a general platform since it can be loaded with different cargos and adapted for targeting of multiple cell types.

引用

收藏

页码：2576 / 2583

页数：8

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