Targeted Drug Delivery in Cancer Cells with Red-Light Photoactivated Mesoporous Silica Nanoparticles

被引：158

作者：

Mackowiak, Stephan A.

Schmidt, Alexandra

Weiss, Veronika

Argyo, Christian

von Schirnding, Constantin

Bein, Thomas ^{[1
]}

Braeuchle, Christoph

机构：

[1] Univ Munich LMU, Dept Chem, D-81377 Munich, Germany

来源：

NANO LETTERS | 2013年 / 13卷 / 06期

关键词：

Mesoporous silica nanoparticles; nanoparticle drug delivery; targeting cancer cells; folic acid; epidermal growth factor; photosensitizer; SUPPORTED LIPID-BILAYERS; GENE DELIVERY; DENDRIMERS; RELEASE; PHOTOSENSITIZER; POLYMERS; VIRUSES; DESIGN; RNA;

D O I：

10.1021/nl400681f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mesoporous nanoparticles for drug delivery would benefit significantly from further improvements in targeting efficiency and endosomal release. We present a system based on colloidal mesoporous silica nanoparticles with targeting-ligands and a red-light photosensitizer. This nanoparticle system provides spatial and temporal control of the release of drugs into the cytosol of cancer cells. Furthermore, the system presents a general platform since it can be loaded with different cargos and adapted for targeting of multiple cell types.

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页码：2576 / 2583

页数：8

相关论文

共 34 条

[1] THE OPTICS OF HUMAN-SKIN [J].

ANDERSON, RR ;

PARRISH, JA .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1981, 77 (01) :13-19

[2] Delivery of Small Interfering RNA by Peptide-Targeted Mesoporous Silica Nanoparticle-Supported Lipid Bilayers [J].

Ashley, Carlee E. ;

Carnes, Eric C. ;

Epler, Katharine E. ;

Padilla, David P. ;

Phillips, Genevieve K. ;

Castillo, Robert E. ;

Wilkinson, Dan C. ;

Wilkinson, Brian S. ;

Burgard, Cameron A. ;

Kalinich, Robin M. ;

Townson, Jason L. ;

Chackerian, Bryce ;

Willman, Cheryl L. ;

Peabody, David S. ;

Wharton, Walker ;

Brinker, C. Jeffrey .

ACS NANO, 2012, 6 (03) :2174-2188

[3]

Ashley CE, 2011, NAT MATER, V10, P389, DOI [10.1038/NMAT2992, 10.1038/nmat2992]

[4]

Behr JP, 1997, CHIMIA, V51, P34

[5] Colchicine-Loaded Lipid Bilayer-Coated 50 nm Mesoporous Nanoparticles Efficiently Induce Microtubule Depolymerization upon Cell Uptake [J].

Cauda, Valentina ;

Engelke, Hanna ;

Sauer, Anna ;

Arcizet, Delphine ;

Brauchle, Christoph ;

Radler, Joachim ;

Bein, Thomas .

NANO LETTERS, 2010, 10 (07) :2484-2492

[6] Targeted Cytosolic Delivery of Cell-Impermeable Compounds by Nanoparticle-Mediated, Light-Triggered Endosome Disruption [J].

Febvay, Sebastien ;

Marini, Davide M. ;

Belcher, Angela M. ;

Clapham, David E. .

NANO LETTERS, 2010, 10 (06) :2211-2219

[7] Peptide- and polymer-based delivery of therapeutic RNA [J].

Froehlich, Thomas ;

Wagner, Ernst .

SOFT MATTER, 2010, 6 (02) :226-234

[8] Cancer therapy improvement with mesoporous silica nanoparticles combining targeting, drug delivery and PDT [J].

Gary-Bobo, Magali ;

Hocine, Ouahiba ;

Brevet, David ;

Maynadier, Marie ;

Raehm, Laurence ;

Richeter, Sebastien ;

Charasson, Virginie ;

Loock, Bernard ;

Morere, Alain ;

Maillard, Philippe ;

Garcia, Marcel ;

Durand, Jean-Olivier .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2012, 423 (02) :509-515

[9] Gold nanoparticles in delivery applications [J].

Ghosh, Partha ;

Han, Gang ;

De, Mrinmoy ;

Kim, Chae Kyu ;

Rotello, Vincent M. .

ADVANCED DRUG DELIVERY REVIEWS, 2008, 60 (11) :1307-1315

[10] Dendrimers and dendritic polymers in drug delivery [J].

Gillies, ER ;

Fréchet, JMJ .

DRUG DISCOVERY TODAY, 2005, 10 (01) :35-43

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