Molecular basis of macrolide-lincosamide-streptogramin (MLS) resistance in Finegoldia magna clinical isolates

被引：5

作者：

Guerin, Francois ^{[1
,2
]}

Lachaal, Sabrine ^{[1
]}

Auzou, Michel ^{[1
,2
]}

Le Brun, Cecile ^{[3
]}

Barraud, Olivier ^{[4
]}

Decousser, Jean-Winoc ^{[5
]}

Lienhard, Reto ^{[6
]}

Baraduc, Regine ^{[7
]}

Dubreuil, Luc ^{[8
]}

Cattoir, Vincent ^{[9
,10
]}

机构：

[1] CHU Caen, Serv Microbiol, F-14033 Caen, France

[2] Univ Caen Normandie, EA4655 Equipe Antibio Resistance, F-14032 Caen, France

[3] CHRU Tours, Hop Bretonneau, Serv Bacteriol Virol, F-37044 Tours, France

[4] CHU Limoges, Lab Bacteriol Virol Hyg, F-87042 Limoges, France

[5] CHU Henri Mondor, AP HP, Lab Microbiol, F-94010 Creteil, France

[6] ADMED Microbiol, CH-2303 La Chaux De Fonds, Switzerland

[7] CHU Clermont Ferrand, Lab Microbiol, F-63003 Clermont Ferrand, France

[8] CHRU Lille, Lab Bacteriol Hyg & Virol, F-59037 Lille, France

[9] CHU Rennes, Serv Bacteriol & Hyg Hospitaliere, 2 Rue Henri Le Guilloux, F-35033 Rennes 9, France

[10] CNR Resistance Antibiot, F-35033 Rennes, France

来源：

ANAEROBE | 2020年 / 64卷

关键词：

F.magna; anaerobes; GPAC; MLS; clindamycin; erm(A); erm(B); POSITIVE ANAEROBIC COCCI; PEPTOSTREPTOCOCCUS; SUSCEPTIBILITY; ELEMENTS;

D O I：

10.1016/j.anaerobe.2020.102220

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Of 69 clinical isolates of Finegoldia magna tested, 36% presented high-level MICs of erythromycin (>256 mu g/ml), harboring erm(A) (n = 20) or erm(B) (n=5). Of nine isolates exhibiting an inducible resistance phenotype to macrolides-lincosamides-streptogramins B, four (44%) were susceptible with a potential risk of treatment failure due to emergence of resistant mutants. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页数：4

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