Peptidomics in drug research

被引：19

作者：

Clynen, E. ^{[1
]}

Baggerman, G. ^{[1
]}

Husson, S. J. ^{[1
]}

Landuyt, B. ^{[1
]}

Schoofs, L. ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Res Grp Funct Genom & Prote, B-3000 Louvain, Belgium

来源：

EXPERT OPINION ON DRUG DISCOVERY | 2008年 / 3卷 / 04期

关键词：

antimicrobial peptide; biomarker; G-protein-coupled receptor; isotopic labeling; iTRAQ; mass spectrometry; neuropeptidomics; peptide toxins; peptidomimetics; TMAB;

D O I：

10.1517/17460441.3.4.425

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background: Because of their wide range of functions, endogenous peptides have great potential either as drugs themselves or as drug targets. Objective: To provide an overview of the current use of peptides as drugs (targets) and describe how improvements in peptide biochemistry and the application of peptidomics studies can lead to the discovery of new diagnostic and therapeutic targets. Methods: We discuss the different peptidomics technologies and their application in the study of human and animal disease models, animal venoms, antimicrobial peptides, G-protein-coupled receptor ligands and biomarkers. Results/conclusions: At present, peptide drugs represent a small but growing number of pharmaceutical molecules. The peptidomics methodology, which was introduced 7 years ago to study naturally occurring peptides, will lead to a plethora of new peptide drug leads.

引用

页码：425 / 440

页数：16

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