A phylo-functional core of gut microbiota in healthy young Chinese cohorts across lifestyles, geography and ethnicities

被引：391

作者：

Zhang, Jiachao ^{[1
]}

Guo, Zhuang ^{[2
]}

Xue, Zhengsheng ^{[3
]}

Sun, Zhihong ^{[1
]}

Zhang, Menghui ^{[3
]}

Wang, Lifeng ^{[1
]}

Wang, Guoyang ^{[3
]}

Wang, Fang ^{[1
]}

Xu, Jie ^{[1
]}

Cao, Hongfang ^{[1
]}

Xu, Haiyan ^{[1
]}

Lv, Qiang ^{[1
]}

Zhong, Zhi ^{[1
]}

Chen, Yongfu ^{[1
]}

Qimuge, Sudu ^{[1
]}

Menghe, Bilige ^{[1
]}

Zheng, Yi ^{[1
]}

Zhao, Liping ^{[3
,4
]}

Chen, Wei ^{[2
]}

Zhang, Heping ^{[1
]}

机构：

[1] Inner Mongolia Agr Univ, Dept Food Sci & Engn, Educ Minist PR China, Key Lab Dairy Biotechnol & Engn, Hohhot 010018, Inner Mongolia, Peoples R China

[2] Jiangnan Univ, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, Wuxi 214122, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, State Key Lab Microbial Metab, Dept Biol Sci, Shanghai 200240, Peoples R China

[4] Shanghai Ctr Syst Biomed, Minist Educ, Key Lab Syst Biomed, Shanghai, Peoples R China

来源：

ISME JOURNAL | 2015年 / 9卷 / 09期

基金：

中国国家自然科学基金;

关键词：

SP-NOV; INFLAMMATORY RESPONSES; INTESTINAL MICROBIOTA; DIETARY FIBER; GEN; NOV; DIVERSITY; FERMENTATION; PROPOSAL; IMPACT; OBESE;

D O I：

10.1038/ismej.2015.11

中图分类号：

Q14 [生态学（生物生态学）];

学科分类号：

071012 ; 0713 ;

摘要：

Structural profiling of healthy human gut microbiota across heterogeneous populations is necessary for benchmarking and characterizing the potential ecosystem services provided by particular gut symbionts for maintaining the health of their hosts. Here we performed a large structural survey of fecal microbiota in 314 healthy young adults, covering 20 rural and urban cohorts from 7 ethnic groups living in 9 provinces throughout China. Canonical analysis of unweighted UniFrac principal coordinates clustered the subjects mainly by their ethnicities/geography and less so by lifestyles. Nine predominant genera, all of which are known to contain short-chain fatty acid producers, co-occurred in all individuals and collectively represented nearly half of the total sequences. Interestingly, species-level compositional profiles within these nine genera still discriminated the subjects according to their ethnicities/geography and lifestyles. Therefore, a phylogenetically diverse core of gut microbiota at the genus level may be commonly shared by distinctive healthy populations as functionally indispensable ecosystem service providers for the hosts.

引用

页码：1979 / 1990

页数：12

共 63 条

[11] Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa [J].