Up-regulation of HOTAIR long non-coding RNA in human gastric adenocarcinoma tissues

被引：107
作者：
Hajjari, Mohammadreza [1 ]
Behmanesh, Mehrdad [1 ]
Sadeghizadeh, Majid [1 ]
Zeinoddini, Mehdi [2 ]
机构：
[1] Tarbiat Modares Univ, Sch Biol Sci, Dept Genet, Tehran, Iran
[2] Mallek Ashtar Univ Technol, Biotechnol Res Ctr, Tehran, Iran
来源：
MEDICAL ONCOLOGY | 2013年 / 30卷 / 03期
关键词：
Long non-coding RNA; HOTAIR; SUZ12; Gastric adenocarcinoma; CANCER; PROGRESSION;
D O I：
10.1007/s12032-013-0670-0
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
HOTAIR is a known long non-coding RNA which has recently been associated with the progression of some cancer types. It has been reported that HOTAIR expression is correlated with SUZ12 expression level and therefore may affect the epigenetic state of cancer tissues. Here, we found aberrant up-regulation of HOTAIR in gastric adenocarcinoma samples compared with normal adjacent gastric epithelium tissues. Besides, we found that the aberrant expression of HOTAIR was associated with TNM staging and lymph node metastasis of gastric tumors. Here, a potential cooperative expression between HOTAIR and SUZ12 genes in gastric adenocarcinoma tissues is deduced. This result suggests a role for HOTAIR long non-coding RNA in gastric cancer progression.
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页数：4
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