BDNF-mediated migration of cardiac microvascular endothelial cells is impaired during ageing

被引：44
作者：
Cao, Liang [1 ,2 ,3 ,4 ]
Zhang, Liang [1 ,2 ,3 ,4 ]
Chen, Siyun [1 ,2 ,3 ]
Yuan, Ziqiang [5 ]
Liu, Shaokun [1 ,2 ,3 ]
Shen, Xiaotao [1 ,2 ,3 ,4 ]
Zheng, Xin [1 ,2 ,3 ,4 ]
Qi, Xufeng [1 ,2 ,3 ,4 ]
Lee, Kenneth K. H. [1 ,2 ,6 ]
Chan, John Yeuk-Hon [1 ,2 ,3 ,4 ]
Cai, Dongqing [1 ,2 ,3 ,4 ]
机构：
[1] Ji Nan Univ, Minist Educ, Key Lab Regenerat Med, Guangzhou 510632, Guangdong, Peoples R China
[2] Jinan Univ, Chinese Univ Hong Kong, Joint Lab Regenerat Med, Guangzhou, Guangdong, Peoples R China
[3] Minist Sci & Technol & Guangdong Prov, Int Base Collaborat Sci & Technol JNU, Guangzhou, Guangdong, Peoples R China
[4] Ji Nan Univ, Dept Dev & Regenerat Biol, Guangzhou 510632, Guangdong, Peoples R China
[5] Albert Einstein Coll Med, Dept Mol Genet, New York, NY USA
[6] Chinese Univ Hong Kong, Sch Biomed Sci, Stem Cell & Regenerat TRP, Hong Kong, Hong Kong, Peoples R China
来源：
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2012年 / 16卷 / 12期
关键词：
ageing; BDNF; cardiac microvascular endothelial cells; migration; TrkB; MYOCARDIAL-INFARCTION; NEUROTROPHIC FACTOR; TRUNCATED TRKB; NERVOUS-SYSTEM; RECEPTORS; ANGIOGENESIS; INFLAMMATION; EXPRESSION; K-252A; INJURY;
D O I：
10.1111/j.1582-4934.2012.01621.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
This study indicates that brain-derived neurotrophic factor (BDNF) can promote young cardiac microvascular endothelial cells (CMECs) to migrate via the activation of the BDNF-TrkB-FL-PI3K/Akt pathway, which may benefit angiogenesis after myocardial infarction (MI). However, the ageing of CMECs led to changes in the expression of receptor Trk isoforms in that among the three isoforms (TrkB-FL, TrkB-T1 and TrkB-T2), only one of its truncated isoforms, TrkB-T1, continued to be expressed, which leads to the dysfunction of its ligand, a decrease in the migration of CMECs and increased injury in ageing hearts. This shift in receptor isoforms in aged CMECs, together with changes in the ageing microenvironment, might predispose ageing hearts to decreased angiogenic potential and increased cardiac pathology.
引用
收藏
页码：3105 / 3115
页数：11
相关论文
共 25 条
[1]   THE TRK FAMILY OF NEUROTROPHIN RECEPTORS [J].
BARBACID, M .
JOURNAL OF NEUROBIOLOGY, 1994, 25 (11) :1386-1403
[2]  
BERG MM, 1992, J BIOL CHEM, V267, P13
[3]   BDNF-mediated enhancement of inflammation and injury in the aging heart [J].
Cai, DQ ;
Holm, JM ;
Duignan, IJ ;
Zheng, JG ;
Xaymardan, M ;
Chin, A ;
Ballard, VLT ;
Bella, JN ;
Edelberg, JM .
PHYSIOLOGICAL GENOMICS, 2006, 24 (03) :191-197
[4]   Age-associated impairment in TNF-α cardioprotection from myocardial infarction [J].
Cai, DQ ;
Xaymardan, M ;
Holm, JM ;
Zheng, JG ;
Kizer, JR ;
Edelberg, JM .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2003, 285 (02) :H463-H469
[5]  
DONOVAN MJ, 1995, AM J PATHOL, V147, P309
[6]  
Donovan MJ, 2000, DEVELOPMENT, V127, P4531
[7]   Phage display identification of age-associated TNFα-mediated cardiac oxidative induction [J].
Edelberg, JM ;
Wong, A ;
Holm, JM ;
Xaymardan, M ;
Duignan, I ;
Chin, A ;
Kizer, JR ;
Cai, DQ .
PHYSIOLOGICAL GENOMICS, 2004, 18 (03) :255-260
[8]   Possible role of brain-derived neurotrophic factor in the pathogenesis of coronary artery disease [J].
Ejiri, J ;
Inoue, N ;
Kobayashi, S ;
Shiraki, R ;
Otsui, K ;
Honjo, T ;
Takahashi, M ;
Ohashi, Y ;
Ichikawa, S ;
Terashima, M ;
Mori, T ;
Awano, K ;
Shinke, T ;
Shite, J ;
Hirata, K ;
Yokozaki, H ;
Kawashima, S ;
Yokoyama, M .
CIRCULATION, 2005, 112 (14) :2114-2120
[9]   Truncated TrkB: Beyond a dominant negative receptor [J].
Fenner, Barbara M. .
CYTOKINE & GROWTH FACTOR REVIEWS, 2012, 23 (1-2) :15-24
[10]   VEGF gene therapy: therapeutic angiogenesis in the clinic and beyond [J].
Giacca, M. ;
Zacchigna, S. .
GENE THERAPY, 2012, 19 (06) :622-629
123