Catalytic enantioselective and catalyst-controlled diastereofacial-selective additions of allyl- and crotylboronates to aldehydes using chiral bronsted acids

被引：96

作者：

Rauniyar, V ^{[1
]}

Hall, DG ^{[1
]}

机构：

[1] Univ Alberta, Dept Chem, Gunning Lemieux Chem Ctr, Edmonton, AB T6G 2G2, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 15期

关键词：

allylation; asymmetric synthesis; Bronsted acids; enantioselective catalysis; stereoselectivity;

D O I：

10.1002/anie.200504432

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Towards the ideal: A chiral diol-SnCl 4 complex is applied to the allylboration of aldehydes (see scheme). This approach highlights the use of chiral Brønsted acid catalysis in the development of an ideal method for the allylation of aldehydes which would display high diastereo- and enantioselectivity, wide substrate scope, and high practicality (ease of use, low cost, and low environmental impact). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2426 / 2428

页数：3

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