The genetic and evolutionary balances in human NK cell receptor diversity

被引：77

作者：

Parham, Peter ^{[1
]}

机构：

[1] Stanford Univ, Dept Biol Struct, Sch Med, Stanford, CA 94305 USA

来源：

SEMINARS IN IMMUNOLOGY | 2008年 / 20卷 / 06期

关键词：

NK cell receptors; Evolution; Diversity; Selection;

D O I：

10.1016/j.smim.2008.10.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In primates and cattle two ancient killer-cell immunoglobulin-like receptor (KIR) lineages independently evolved to become diverse NK cell receptors. In mice, KIR genes were sidelined to the X chromosome, a possible consequence of pathogen-mediated selection on the receptor for IgA-Fc. In humans. KIR uniquely form two omnipresent ha lot type groups (A and B), postulated here to play complementary and necessary roles in immune defense and reproduction. The basis of KIR3DL1/JS1 polymorphism is three ancient lineages maintained by long-term balancing selection and present in all human populations. Conserved and variable NK cell receptors produce structurally diverse NK cell receptor repertoires within a defined range of missing-self-response. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：311 / 316

页数：6

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