Optical detection of synaptic vesicle exocytosis and endocytosis

被引：32
作者：
Murthy, VN [1 ]
机构：
[1] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA
来源：
CURRENT OPINION IN NEUROBIOLOGY | 1999年 / 9卷 / 03期
关键词：
D O I：
10.1016/S0959-4388(99)80046-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Recent advances in optical methods have catalyzed a detailed study of individual visualized synapses in several model systems. Quantal events at small central synapses, as well as single granule exocytosis in secretory cells, have been detected using quantitative fluorescence imaging. Sensitive detection of exocytosis and endocytosis at individual synapses has advanced our knowledge of synaptic vesicle trafficking.
引用
收藏
页码：314 / 320
页数：7
相关论文
共 51 条
  • [1] The exocytotic event in chromaffin cells revealed by patch amperometry
    Albillos, A
    Dernick, G
    Horstmann, H
    Almers, W
    deToledo, GA
    Lindau, M
    [J]. NATURE, 1997, 389 (6650) : 509 - 512
  • [2] Axelrod D, 1991, TOPICS FLUORESCENCE, V3, P289
  • [3] Imaging exocytosis and endocytosis
    Betz, WJ
    Mao, F
    Smith, CB
    [J]. CURRENT OPINION IN NEUROBIOLOGY, 1996, 6 (03) : 365 - 371
  • [4] OPTICAL ANALYSIS OF SYNAPTIC VESICLE RECYCLING AT THE FROG NEUROMUSCULAR-JUNCTION
    BETZ, WJ
    BEWICK, GS
    [J]. SCIENCE, 1992, 255 (5041) : 200 - 203
  • [5] Pre- and postsynaptic whole-cell recordings in the medial nucleus of the trapezoid body of the rat
    Borst, JGG
    Helmchen, F
    Sakmann, B
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 1995, 489 (03): : 825 - 840
  • [6] Neuronal peptide release is limited by secretory granule mobility
    Burke, NV
    Han, WP
    Li, DQ
    Takimoto, K
    Watkins, SC
    Levitan, ES
    [J]. NEURON, 1997, 19 (05) : 1095 - 1102
  • [7] Chow Robert H., 1995, P245
  • [8] Photon upmanship: Why multiphoton imaging is more than a gimmick
    Denk, W
    Svoboda, K
    [J]. NEURON, 1997, 18 (03) : 351 - 357
  • [9] SUBTHRESHOLD SYNAPTIC CA2+ SIGNALING IN FINE DENDRITES AND SPINES OF CEREBELLAR PURKINJE NEURONS
    EILERS, J
    AUGUSTINE, GJ
    KONNERTH, A
    [J]. NATURE, 1995, 373 (6510) : 155 - 158
  • [10] Single synaptic events evoke NMDA receptor-mediated release of calcium from internal stores in hippocampal dendritic spines
    Emptage, N
    Bliss, TVP
    Fine, A
    [J]. NEURON, 1999, 22 (01) : 115 - 124
123456