Mutator bacteria as a risk factor in treatment of infectious diseases

被引：82

作者：

Giraud, A

Matic, I

Radman, M

Fons, M

Taddei, F

机构：

[1] Univ Paris 05, Fac Med Necker Enfants Malad, INSERM, E9916, F-75015 Paris, France

[2] INRA, UEPSD, FBI, CRJ, F-78352 Jouy En Josas, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 03期

关键词：

D O I：

10.1128/AAC.46.3.863-865.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We show in a gnotobiotic mouse model that, in addition to direct selection of antibiotic-resistant bacteria, some antibiotic treatments also select for mutator alleles. Because of these mutator alleles' high mutation rates, the initial treatment failure increases the probability of failures in subsequent treatments with other drugs.

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页码：863 / 865

页数：3

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