Brief report - Oseltamivir resistance during treatment of influenza A (H5N1) infection

被引：678

作者：

de Jong, MD

Thanh, TT

Khanh, TH

Hien, VM

Smith, GJD

Chau, NV

Cam, BV

Qui, PT

Ha, DQ

Guan, Y

Peiris, JSM

Hien, TT

Farrar, J

机构：

[1] Univ Oxford, Hosp Trop Dis, Clin Res Unit, Ho Chi Minh City, Vietnam

[2] Pediat Hosp 1, Ho Chi Minh City, Vietnam

[3] Univ Hong Kong, Queen Mary Hosp, Dept Microbiol, Hong Kong, Hong Kong, Peoples R China

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2005年 / 353卷 / 25期

基金：

英国惠康基金;

关键词：

D O I：

10.1056/NEJMoa054512

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Influenza A (H5N1) virus with an amino acid substitution in neuraminidase conferring high-level resistance to oseltamivir was isolated from two of eight Vietnamese patients during oseltamivir treatment. Both patients died of influenza A (H5N1) infection, despite early initiation of treatment in one patient. Surviving patients had rapid declines in the viral load to undetectable levels during treatment. observations suggest that resistance can emerge during the currently recommended regimen of oseltamivir therapy and may be associated with clinical deterioration and that the strategy for the treatment of influenza A ( H5N1) virus infection include additional antiviral agents.

引用

页码：2667 / 2672

页数：6

共 17 条

[1] Current concepts - Avian influenza A (H5N1) infection in humans [J].

Beigel, H ;

Farrar, H ;

Han, AM ;

Hayden, FG ;

Hyer, R ;

de Jong, MD ;

Lochindarat, S ;

Tien, NTK ;

Hien, NT ;

Hien, TT ;

Nicoll, A ;

Touch, S ;

Yuen, KY .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (13) :1374-1385

[2] RAPID AND SIMPLE METHOD FOR PURIFICATION OF NUCLEIC-ACIDS [J].

BOOM, R ;

SOL, CJA ;

SALIMANS, MMM ;

JANSEN, CL ;

WERTHEIMVANDILLEN, PME ;

VANDERNOORDAA, J .

JOURNAL OF CLINICAL MICROBIOLOGY, 1990, 28 (03) :495-503

[3] Improved silica-guanidiniumthiocyanate DNA isolation procedure based on selective binding of bovine alpha-casein to silica particles [J].

Boom, R ;

Sol, C ;

Beld, M ;

Weel, J ;

Goudsmit, J ;

Wertheim-van Dillen, P .

JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (03) :615-619

[4] H5N1 virus outbreak in migratory waterfowl [J].

Chen, H ;

Smith, GJD ;

Zhang, SY ;

Qin, K ;

Wang, J ;

Li, KS ;

Webster, RG ;

Peiris, JSM ;

Guan, Y .

NATURE, 2005, 436 (7048) :191-192

[5] Human disease from influenza A (H5N1), Thailand, 2004 [J].

Chotpitayasunondh, T ;

Ungchusak, K ;

Hanshaoworakul, W ;

Chunsuthiwat, S ;

Sawanpanyalert, P ;

Kijphati, R ;

Lochindarat, S ;

Srisan, P ;

Suwan, P ;

Osotthanakorn, Y ;

Anantasetagoon, T ;

Kanjanawasri, S ;

Tanupattarachai, S ;

Weerakul, J ;

Chaiwirattana, R ;

Maneerattanaporn, M ;

Poolsavatkitikool, R ;

Chokephaibulkit, K ;

Apisarnthanarak, A ;

Dowell, SF .

EMERGING INFECTIOUS DISEASES, 2005, 11 (02) :201-209

[6] Brief report: Fatal avian influenza A (H5N1) in a child presenting with diarrhea followed by coma [J].

de Jong, MD ;

Van Cam, B ;

Qui, PT ;

Hien, VM ;

Thanh, TT ;

Hue, NB ;

Beld, M ;

Phuong, LT ;

Khanh, TH ;

Chau, NVV ;

Hien, TT ;

Ha, DQ ;

Farrar, J .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (07) :686-691

[7] Selection of influenza virus mutants in experimentally infected volunteers treated with oseltamivir [J].

Gubareva, LV ;

Kaiser, L ;

Matrosovich, MN ;

Soo-Hoo, Y ;

Hayden, FG .

JOURNAL OF INFECTIOUS DISEASES, 2001, 183 (04) :523-531

[8] Avian influenza A (H5N1) in 10 patients in Vietnam. [J].

Hien, TT ;

Liem, NT ;

Dung, NT ;

San, LT ;

Mai, PP ;

Chau, NVV ;

Suu, PT ;

Dong, VC ;

Mai, LTQ ;

Thi, NT ;

Khoa, DB ;

Phat, LP ;

Truong, NT ;

Long, HT ;

Tung, CV ;

Giang, LT ;

Tho, ND ;

Nga, LH ;

Tien, NTK ;

San, LH ;

Tuan, LV ;

Dolecek, C ;

Thanh, TT ;

de Jong, M ;

Schultsz, C ;

Cheng, P ;

Lim, W ;

Horby, P ;

Farrar, J .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (12) :1179-1188

[9] Resistant influenza A viruses in children treated with oseltarnivir: descriptive study [J].

Kiso, M ;

Mitamura, K ;

Sakai-Tagawa, Y ;

Shiraishi, K ;

Kawakami, C ;

Kimura, K ;

Hayden, FG ;

Sugaya, N ;

Kawaoka, Y .

LANCET, 2004, 364 (9436) :759-765

[10] Avian flu - Isolation of drug-resistant H5N1 virus [J].

Le, QM ;

Kiso, M ;

Someya, K ;

Sakai, YT ;

Nguyen, TH ;

Nguyen, KHL ;

Pham, ND ;

Ngyen, HH ;

Yamada, S ;

Muramoto, Y ;

Horimoto, T ;

Takada, A ;

Goto, H ;

Suzuki, T ;

Suzuki, Y ;

Kawaoka, Y .

NATURE, 2005, 437 (7062) :1108-1108

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