Synthesis of the hydrophilic phosphine complex Cu(DHMPE)2+ from Cu(I) chloride (DHMPE=1,2-bis[(dihydroxymethyl)phosphino]ethane, a water-soluble bidentate phosphine)

被引：0

作者：

Nell, Bryan P. ^{[1
]}

Swor, Charles D. ^{[1
]}

Zakharov, Lev N. ^{[1
]}

Tyler, David R. ^{[1
]}

机构：

[1] Univ Oregon, Dept Chem, Eugene, OR 97403 USA

来源：

POLYHEDRON | 2012年 / 45卷 / 01期

基金：

美国国家科学基金会;

关键词：

Copper phosphine complex; Water-soluble phosphine; Water-soluble coordination complex; Biomedically useful metal complex; COPPER(I) COMPLEXES; QUADRUPOLE RELAXATION; CRYSTAL-STRUCTURE; RHODIUM COMPLEX; REACTIVITY; LIGAND; DMPE; ION;

D O I：

10.1016/j.poly.2012.07.053

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The biomedically useful Cu(DHMPE)(2)(+) complex (DHMPE = 1,2-bis[(dihydroxymethyl)phosphino]ethane, a water-soluble bidentate phosphine) is normally synthesized from expensive Cu(I) sources because the use of cheaper CuCl can lead to a variety of unwanted coordination complex by-products. A method is reported for the synthesis of Cu(DHMPE)(2)(+) from CuCl. Reaction of CuCl with DHMPE in methanol gave [Cu(DHMPE)(2)]Cl, which is soluble in water and moderately soluble in methanol. The complex crystallized as a phosphine-bridged dimer, [Cu-2(DHMPE)(4)]Cl-2, but H-1 NMR DOSY experiments indicated the complex is mononuclear in solution. Reaction of CuCl with DHMPE in THF did not yield Cu(DHMPE)(2)(+), except when a halide abstractor such as NaPF6 was added. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：30 / 34

页数：5

共 23 条

[1] Synthesis, in vitro and in vivo characterization of 64Cu(I) complexes derived from hydrophilic tris(hydroxymethyl)phosphane and 1,3,5-triaza-7-phosphaadamantane ligands [J].