Facile synthesis of polysubstituted 2,3-dihydropyrroles and pyrroles from Mn(OAc)3-promoted oxidative cyclization of alkenes with amines/alkyne esters or enaminone esters

被引：12
作者：
Zeng, Ji-Chao [1 ]
Xu, Hui [1 ]
Huang, Rong-Lu [1 ]
Yu, Fei [1 ]
Zhang, Ze [1 ]
机构：
[1] Anhui Polytech Univ, Sch Biol & Chem Engn, Wuhu 241000, Peoples R China
来源：
TETRAHEDRON LETTERS | 2018年 / 59卷 / 16期
关键词：
Manganese (III) acetate; Polysubstituted 2,3-dihydropyrroles; Polysubstituted pyrroles; Oxidative cyclization; TANDEM MICHAEL/CYCLIZATION SEQUENCE; POLYFUNCTIONAL DIHYDROPYRROLE; DERIVATIVES; ALKALOIDS; N-SULFONYL-1,2,3-TRIAZOLES; CYCLOISOMERIZATION; TRANSANNULATION; SIBIROMYCIN; ANNULATION; AMINES;
D O I：
10.1016/j.tetlet.2018.03.025
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel oxidative cyclization of alkenes with amines/alkyne esters or enaminone esters can be efficiently promoted by Mn(OAc)(3), furnishing a series of polysubstituted 2,3-dihydropyrroles in moderate to excellent isolated yields (75-91%). Afterward addition of a suitable oxidant such as K2S2O8 can furnish efficient synthesis of the corresponding polysubstituted pyrroles in a one-pot pathway. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1576 / 1580
页数：5
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