CD8+ CTLs are essential for protective immunity against Encephalitozoon cuniculi infection

被引:0
|
作者
Khan, IA
Schwartzman, JD
Kasper, LH
Moretto, M
机构
[1] Dartmouth Med Sch, Dept Med & Microbiol, Lebanon, NH 03756 USA
[2] Dartmouth Med Sch, Dept Pathol, Lebanon, NH 03756 USA
来源
JOURNAL OF IMMUNOLOGY | 1999年 / 162卷 / 10期
关键词
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Encephalitozoon cuniculi is a protozoan parasite that has been implicated recently as a cause of opportunistic infection in immunocompromised individuals. Protective immunity in the normal host is T cell-dependent. In the present study, the role of individual T cell subtypes in immunity against this parasite has been studied using gene knockout mice. Whereas CD4(-/-) animals resolved the infection, mice lacking CD8(+) T cells or perforin gene succumbed to parasite challenge. The data obtained in these studies suggest that E, cuniculi infection induces a strong and early CD8(+) T response that is important for host protection. The CD8(+) T cell-mediated protection depends upon the CTL activity of this cell subset, as the host is rendered susceptible to infection in the absence of this function. This is the first report in which a strong dependence upon the cytolytic activity of host CD8(+) T cells has been shown to be important in a parasite infection.
引用
收藏
页码:6086 / 6091
页数:6
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