Pediatric Brain Tumors and Epilepsy

被引：18
作者：
Wells, Elizabeth M. [1 ,2 ,3 ]
Gaillard, William D. [2 ,3 ,4 ]
Packer, Roger J. [2 ,3 ]
机构：
[1] Childrens Natl Med Ctr, Dept Neurol, Brain Tumor Inst, Washington, DC 20010 USA
[2] Childrens Natl Med Ctr, Ctr Neurosci & Behav Med, Washington, DC 20010 USA
[3] George Washington Univ, Dept Neurol & Pediat, Washington, DC USA
[4] Childrens Natl Med Ctr, Comprehens Pediat Epilepsy Program, Washington, DC 20010 USA
来源：
SEMINARS IN PEDIATRIC NEUROLOGY | 2012年 / 19卷 / 01期
关键词：
NEUROLOGIC SEQUELAE; PRESENTING SYMPTOM; ADULT SURVIVORS; GRADE GLIOMAS; RISK-FACTORS; CHILDREN; SEIZURES; THERAPY; DRUGS;
D O I：
10.1016/j.spen.2012.02.010
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Seizures are a common complication of pediatric brain tumors and their treatment. This article reviews the epidemiology, evaluation, and treatment of seizures in children with brain tumors. Seizures in known brain tumor patients may signify tumor progression or recurrence, or treatment-related brain damage, as well as other causes, including low drug levels and metabolic disturbances. Careful selection of antiepileptic medications is needed in this population. There are advantages to nonenzyme-inducing antiepileptic drugs including valproic acid, which has potential antitumoral properties as a histone deacetylase inhibitor. Tumor surgery cures many cases of pediatric tumor-associated seizures, and some children are controlled with anti-epileptic medication, however additional epilepsy surgery may be needed for refractory cases. Semin Pediatr Neurol 19:3-8 (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：3 / 8
页数：6
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