Antinociceptive and Anti-Inflammatory Effects of Total Alkaloid Extract from Fumaria capreolata

被引：8

作者：

Bribi, Noureddine ^{[1
,2
]}

Algieri, Francesca ^{[1
]}

Rodriguez-Nogales, Alba ^{[1
]}

Garrido-Mesa, Jose ^{[1
]}

Vezza, Teresa ^{[1
]}

Maiza, Fadila ^{[2
]}

Pilar Utrilla, Maria ^{[1
]}

Elena Rodriguez-Cabezas, Maria ^{[1
]}

Galvez, Julio ^{[1
]}

机构：

[1] Univ Granada, Ctr Biomed Res CIBM, Ibs GRANADA, Dept Pharmacol,CIBER EHD, Granada 18100, Spain

[2] Univ Bejaia, Fac Nat Sci & Life, Lab Plant Biotechnol & Ethnobot, Bejaia 06000, Algeria

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2015年 / 2015卷

关键词：

FORMALIN TEST; ACID;

D O I：

10.1155/2015/736895

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Fumaria capreolata is used in traditional medicine in North Africa for its gastrointestinal and anti-inflammatory activities. The present study investigates the effects of total alkaloids extracted from the aerial parts of Fumaria capreolata (AFC) on LPS-induced production of proinflammatory mediators (IL-6, IL-1 beta, iNOS, TNF-alpha, COX-2, and MIP-2) in RAW264.7 cells. AFC significantly reduced the inflammatory response inhibiting the production of nitric oxide (NO) and IL-6 in a dose-dependent manner, without affecting the viability of cells, and downregulated mRNA expression of proinflammatory key players: IL-6, IL-1 beta, iNOS, TNF-alpha, and COX-2. AFC antinociceptive and anti-inflammatory properties were also evaluated on the acetic acid-and formalin-induced pain models in mice. AFC oral administration significantly inhibited acetic acid-induced writhes and reduced formalin-induced paw licking time. Therefore, AFC may be a potential candidate for the treatment of inflammatory diseases, such as colitis and arthritis.

引用

页数：7

共 28 条

[1]

51Raj P P., 1996, Pain Medicine, V1st, P12

[2]

De Nardin E, 2001, Ann Periodontol, V6, P30, DOI 10.1902/annals.2001.6.1.30

[3] Anti-inflammatory and analgesic activities of mature fresh leaves of Vitex negundo [J].