Isosorbide delays gentamicin-induced vestibular sensory cell death

被引：1
|
作者：
Takumida, M
Anniko, M
机构：
[1] Hiroshima Univ, Fac Med, Dept Otolaryngol, Minami Ku, Hiroshima 7348551, Japan
[2] Univ Uppsala Hosp, Dept Otolaryngol Head & Neck Surg, Uppsala, Sweden
来源：
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES | 2005年 / 67卷 / 05期
关键词：
vestibular sensory cell; gentamicin; nitric oxide; free radicals; isosorbide;
D O I：
10.1159/000089408
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
The efficacy of isosorbide for protection from vestibular sensory cell damage was investigated. The effects of isosorbide on gentamicin-induced production of nitric oxide ( NO) and reactive oxygen species (ROS) were studied by means of the fluorescence indicators 4,5-diaminofluorescein diacetate and dihydrotetramethylrosamine. The effect on gentamicin-induced vestibular sensory cell damage was examined by using an in vitro LIVE/DEAD system. Isosorbide inhibited the production of both NO and ROS. Isosorbide limited the vestibular sensory cell damage caused by gentamicin. It is, therefore, suggested that isosorbide may help to treat inner ear disorders. Copyright (C) 2005 S. Karger AG, Basel.
引用
收藏
页码：276 / 281
页数：6
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