Isosorbide delays gentamicin-induced vestibular sensory cell death

被引：1
|
作者：
Takumida, M
Anniko, M
机构：
[1] Hiroshima Univ, Fac Med, Dept Otolaryngol, Minami Ku, Hiroshima 7348551, Japan
[2] Univ Uppsala Hosp, Dept Otolaryngol Head & Neck Surg, Uppsala, Sweden
来源：
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES | 2005年 / 67卷 / 05期
关键词：
vestibular sensory cell; gentamicin; nitric oxide; free radicals; isosorbide;
D O I：
10.1159/000089408
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
The efficacy of isosorbide for protection from vestibular sensory cell damage was investigated. The effects of isosorbide on gentamicin-induced production of nitric oxide ( NO) and reactive oxygen species (ROS) were studied by means of the fluorescence indicators 4,5-diaminofluorescein diacetate and dihydrotetramethylrosamine. The effect on gentamicin-induced vestibular sensory cell damage was examined by using an in vitro LIVE/DEAD system. Isosorbide inhibited the production of both NO and ROS. Isosorbide limited the vestibular sensory cell damage caused by gentamicin. It is, therefore, suggested that isosorbide may help to treat inner ear disorders. Copyright (C) 2005 S. Karger AG, Basel.
引用
收藏
页码：276 / 281
页数：6
相关论文
共 50 条
  • [21] Protective effect of nebivolol on gentamicin-induced nephrotoxicity in rats
    Dursun, M.
    Sahin, S.
    Besiroglu, H.
    Otunctemur, A.
    Ozbek, E.
    Cakir, S. S.
    Cekmen, M.
    Somay, A.
    BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, 2018, 119 (11): : 718 - 725
  • [22] Protective Effect of Grape Seed Extract on Gentamicin-Induced Acute Kidney Injury
    Safa, Javid
    Argani, Hassan
    Bastani, Bahar
    Nezami, Nariman
    Ardebili, Babak Rahimi
    Ghorbanihaghjo, Amir
    Kalagheichi, Hassan
    Amirfirouzi, Akbar
    Mesgari, Mehran
    Rad, Jafar Soleimany
    IRANIAN JOURNAL OF KIDNEY DISEASES, 2010, 4 (04) : 285 - 291
  • [23] EFFECT OF DEXTRAN ON GENTAMICIN-INDUCED OTOTOXICITY
    MANABE, Y
    SAITO, T
    TSUZUKI, H
    IGARASHI, M
    YAMAGISHI, T
    SAITO, H
    ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES, 1995, 57 (03): : 111 - 114
  • [24] A Novel Active Peptide from Rapana venosa Protects Against Gentamicin-Induced Sensory Hair Cell Loss in Zebrafish
    Yan Gao
    Shanshan Zhang
    Jiahui Wan
    Rongchun Wang
    Shuaikang Ba
    Xiuna Ji
    Chen Sun
    Kechun Liu
    International Journal of Peptide Research and Therapeutics, 2021, 27 : 641 - 649
  • [25] Effects of pentoxifylline on gentamicin-induced nephrotoxicity
    Kasap, Belde
    Turkmen, Mehmet
    Kiray, Muge
    Kuralay, Filiz
    Soylu, Alper
    Tugyan, Kazim
    Kavukcu, Salih
    RENAL FAILURE, 2013, 35 (10) : 1376 - 1381
  • [26] Effect of carnosine on gentamicin-induced nephrotoxicity
    Soliman, Kawther M.
    Abdul-Hamid, Manal
    Othman, Amel I.
    MEDICAL SCIENCE MONITOR, 2007, 13 (03): : BR73 - BR83
  • [27] Experimental gentamicin-induced nephrotoxicity in the sheep
    Fartashvand, Majid
    Mousavi, Ghafour
    Hajisadeghi, Yaghoub
    BULLETIN OF THE VETERINARY INSTITUTE IN PULAWY, 2014, 58 (04) : 657 - 661
  • [28] Gentamicin attenuates gentamicin-induced ototoxicity - Self-protection
    Maudonnet, Eloisa Nogueira
    de Oliveira, Jose Antonio A.
    Rossato, Maria
    Hyppolito, Miguel Angelo
    DRUG AND CHEMICAL TOXICOLOGY, 2008, 31 (01) : 11 - 25
  • [29] Gentamicin-induced apoptosis in renal cell lines and embryonic rat fibroblasts
    El Mouedden, M
    Laurent, G
    Mingeot-Leclercq, MP
    Tulkens, PM
    TOXICOLOGICAL SCIENCES, 2000, 56 (01) : 229 - 239
  • [30] Heme Oxygenase-1 Protects Hair Cells From Gentamicin-Induced Death
    Yang, Yang
    Chen, Xin
    Tian, Keyong
    Tian, Chaoyong
    Chen, Liyang
    Mi, Wenjuan
    Li, Qiong
    Qiu, Jianhua
    Lin, Ying
    Zha, Dingjun
    FRONTIERS IN CELLULAR NEUROSCIENCE, 2022, 16
12345