Intracellular expression of FLT3 in Purkinje cells: implications for adoptive T-cell therapies

被引:12
作者
Cakmak-Goeruer, Nese [1 ,2 ,3 ,4 ,5 ]
Radke, Josefine [3 ,4 ,5 ,6 ,7 ,8 ]
Rhein, Simone [2 ,3 ,4 ,5 ]
Schumann, Elisa [3 ,4 ,5 ,6 ,7 ,8 ]
Willimsky, Gerald [3 ,4 ,5 ,7 ,8 ,9 ,10 ]
Heppner, Frank L. [3 ,4 ,5 ,6 ,7 ,8 ,11 ]
Blankenstein, Thomas [1 ,3 ,4 ,5 ]
Pezzutto, Antonio [1 ,2 ,3 ,4 ,5 ]
机构
[1] Helmholtz Assoc, Max Delbruck Ctr Mol Med, Berlin, Germany
[2] Charite, Berlin, Germany
[3] Free Univ Berlin, Berlin, Germany
[4] Humboldt Univ, Berlin, Germany
[5] Berlin Inst Hlth, Berlin, Germany
[6] Charite Univ Med Berlin, Dept Neuropathol, Berlin, Germany
[7] German Canc Consortium DKTK, Heidelberg, Germany
[8] Partner Site Berlin, Berlin, Germany
[9] Charite, Inst Immunol, Berlin, Germany
[10] German Canc Res Ctr, Heidelberg, Germany
[11] German Ctr Neurodegenerat Dis DZNE, Berlin, Germany
关键词
ACUTE MYELOID-LEUKEMIA; ANTIGEN; GENE;
D O I
10.1038/s41375-018-0330-7
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:1039 / 1043
页数:5
相关论文
共 15 条
[1]   Targeting FLT3 by chimeric antigen receptor T cells for the treatment of acute myeloid leukemia [J].
Chen, L. ;
Mao, H. ;
Zhang, J. ;
Chu, J. ;
Devine, S. ;
Caligiuri, M. A. ;
Yu, J. .
LEUKEMIA, 2017, 31 (08) :1830-1834
[2]  
Chien CD, 2016, AM SOC HEMATOL, V128, P1072
[3]  
DELAPEYRIERE O, 1995, DIFFERENTIATION, V58, P351, DOI 10.1007/s002580050094
[4]   Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor-modified T cells [J].
Gill, Saar ;
Tasian, Sarah K. ;
Ruella, Marco ;
Shestova, Olga ;
Li, Yong ;
Porter, David L. ;
Carroll, Martin ;
Danet-Desnoyers, Gwenn ;
Scholler, John ;
Grupp, Stephan A. ;
June, Carl H. ;
Kalos, Michael .
BLOOD, 2014, 123 (15) :2343-2354
[5]   CAR T-cells targeting FLT3 have potent activity against FLT3-ITD+ AML and act synergistically with the FLT3-inhibitor crenolanib [J].
Jetani, Hardikkumar ;
Garcia-Cadenas, Irene ;
Nerreter, Thomas ;
Thomas, Simone ;
Rydzek, Julian ;
Briones Meijide, Javier ;
Bonig, Halvard ;
Herr, Wolfgang ;
Sierra, Jordi ;
Einsele, Hermann ;
Hudecek, Michael .
LEUKEMIA, 2018, 32 (05) :1168-1179
[6]   CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia [J].
Kenderian, S. S. ;
Ruella, M. ;
Shestova, O. ;
Klichinsky, M. ;
Aikawa, V. ;
Morrissette, J. J. D. ;
Scholler, J. ;
Song, D. ;
Porter, D. L. ;
Carroll, M. ;
June, C. H. ;
Gill, S. .
LEUKEMIA, 2015, 29 (08) :1637-1647
[7]   Transgenic mice with a diverse human T cell antigen receptor repertoire [J].
Li, Liang-Ping ;
Lampert, J. Christoph ;
Chen, Xiaojing ;
Leitao, Catarina ;
Popovic, Jelena ;
Mueller, Werner ;
Blankenstein, Thomas .
NATURE MEDICINE, 2010, 16 (09) :1029-U127
[8]   TARGETED DISRUPTION OF THE FLK2/FLT3 GENE LEADS TO DEFICIENCIES IN PRIMITIVE HEMATOPOIETIC PROGENITORS [J].
MACKAREHTSCHIAN, K ;
HARDIN, JD ;
MOORE, KA ;
BOAST, S ;
GOFF, SP ;
LEMISCHKA, IR .
IMMUNITY, 1995, 3 (01) :147-161
[9]   T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters [J].
Manza, Boryana N. ;
Jackson, Bryan L. ;
Petit, Rebecca S. ;
Dustin, Michael L. ;
Groves, Jay .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (22) :9089-9094
[10]   Cancer regression in patients after transfer of genetically engineered lymphocytes [J].
Morgan, Richard A. ;
Dudley, Mark E. ;
Wunderlich, John R. ;
Hughes, Marybeth S. ;
Yang, James C. ;
Sherry, Richard M. ;
Royal, Richard E. ;
Topalian, Suzanne L. ;
Kammula, Udai S. ;
Restifo, Nicholas P. ;
Zheng, Zhili ;
Nahvi, Azam ;
de Vries, Christiaan R. ;
Rogers-Freezer, Linda J. ;
Mavroukakis, Sharon A. ;
Rosenberg, Steven A. .
SCIENCE, 2006, 314 (5796) :126-129