Salvage Bacteriophage Therapy for a Chronic MRSA Prosthetic Joint Infection

被引：80

作者：

Doub, James B. ^{[1
]}

Ng, Vincent Y. ^{[2
]}

Johnson, Aaron J. ^{[2
]}

Slomka, Magdalena ^{[1
]}

Fackler, Joseph ^{[3
]}

Horne, Bri'Anna ^{[3
]}

Brownstein, Michael J. ^{[3
]}

Henry, Matthew ^{[4
]}

Malagon, Francisco ^{[4
]}

Biswas, Biswajit ^{[4
]}

机构：

[1] Univ Maryland, Div Infect Dis, Sch Med, Baltimore, MD 21201 USA

[2] Univ Maryland, Sch Med, Dept Orthoped Surg, Baltimore, MD 21201 USA

[3] Adapt Phage Therapeut, Gaithersburg, MD 20878 USA

[4] Naval Med Res Ctr, Biol Def Res Directorate, Ft Detrick, MD 21702 USA

来源：

ANTIBIOTICS-BASEL | 2020年 / 9卷 / 05期

关键词：

bacteriophage therapy; prosthetic joint infection; methicillin resistance Staphylococcus aureus; medication induced hepatitis; biofilm;

D O I：

10.3390/antibiotics9050241

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

This is a case of a 72 year old male with a chronic methicillin-resistant Staphylococcus aureus prosthetic joint infection. After the third intravenous dose of bacteriophage therapy, an unusual, reversible transaminitis prompted stoppage of bacteriophage therapy. Nevertheless, treatment was successful and the patient's severe chronic infection was eradicated.

引用

页数：6

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