The correlations between Th1 and Th2 cytokines in human alveolar echinococcosis

被引：15

作者：

Ma, Xiao ^{[1
]}

Zhang, Xuefei ^{[1
]}

Liu, Jia ^{[1
]}

Liu, Yufang ^{[1
]}

Zhao, Cunzhe ^{[1
]}

Cai, Huixia ^{[1
]}

Lei, Wen ^{[1
]}

Ma, Junying ^{[1
]}

Fan, Haining ^{[2
]}

Zhou, Jianye ^{[3
]}

Liu, Na ^{[1
]}

Zhang, Jingxiao ^{[1
]}

Wang, Yongshun ^{[1
]}

Wang, Wei ^{[1
]}

Zhan, Peizhen ^{[1
]}

Zhang, Xiongying ^{[1
]}

Zhang, Qing ^{[1
]}

Shi, Kemei ^{[1
]}

Liu, Peiyun ^{[1
]}

机构：

[1] Qinghai Inst Endem Dis Prevent & Control, Xining 811602, Qinghai, Peoples R China

[2] Qinghai Univ Affiliated Hosp, Xining 810000, Qinghai, Peoples R China

[3] Northwest Minzu Univ, Biomed Res Ctr, Lanzhou 730000, Gansu, Peoples R China

来源：

BMC INFECTIOUS DISEASES | 2020年 / 20卷 / 01期

关键词：

Alveolar echinococcosis; Echinococcus multilocularis; Th1; cytokines; Th2; Correlation analysis; IN-VIVO TREATMENT; MULTILOCULARIS INFECTION; IMMUNE-RESPONSE; IFN-GAMMA; CHEMOKINE; PROFILE; CELLS; GROWTH; LIVER; SERUM;

D O I：

10.1186/s12879-020-05135-y

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background Alveolar echinococcosis (AE) is a zoonotic parasitic disease caused byEchinococcus multilocularislarval tapeworm infections in humans that severely impairs the health of affected patients in the northern hemisphere. Methods The expression levels of 20 cytokines associated with AE infection were measured by enzyme-linked immunosorbent assay, and the correlations between these cytokines were analysed in the R programming language. Results Serum cytokine levels differed among individuals in both the AE patient and healthy control groups. The results of the correlations among the cytokines showed obvious differences between the two groups. In the AE patients group, Th1 and Th2 cytokines formed a more complicated network than that in the healthy control group. Conclusions The altered correlations between Th1 and Th2 cytokines may be closely associated with AE infection, which may provide a new explanation for the essential differences between AE patients and healthy individuals.

引用

页数：8

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