Expression and function of ErbB receptors and ligands in the pituitary

被引：54

作者：

Cooper, Odelia ^{[1
]}

Vlotides, George ^{[2
]}

Fukuoka, Hidenori ^{[1
]}

Greene, Mark I. ^{[3
,4
]}

Melmed, Shlomo ^{[1
]}

机构：

[1] Cedars Sinai Med Ctr, Dept Med, Pituitary Ctr, Los Angeles, CA 90048 USA

[2] Univ Munich, Dept Med 2, Univ Hosp Munich Grosshadern, Munich, Germany

[3] Cedars Sinai Med Ctr, Dept Biomed Sci & Pathol & Lab Med, Los Angeles, CA 90048 USA

[4] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

关键词：

EPIDERMAL-GROWTH-FACTOR; GONADOTROPIN-RELEASING-HORMONE; RAT ANTERIOR-PITUITARY; FACTOR-BINDING-SITES; FACTOR-ALPHA; LUTEINIZING-HORMONE; REPRODUCTIVE FUNCTION; GENE-EXPRESSION; MESSENGER-RNA; GH4C1; CELLS;

D O I：

10.1530/ERC-11-0066

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The role of ErbB family in discreet pituitary functions is reviewed. Several ErbB receptor ligands, EGF, TGF alpha, and heregulin are differentially expressed in normal gonadotroph and lactosomatotroph lineages, and other elements of the anterior pituitary. ErbB receptors, i.e. EGFR and ErbB2, are also localized to the anterior pituitary with preferential EGFR lactosomatotroph expression. EGF regulates CRH and ACTH secretion and corticotroph proliferation as well as exhibiting autocrine and paracrine effects on gonadotrophs and on lactosomatotroph proliferation, gene and protein expression, and hormonal secretion. EGF and EGFR are expressed in both functioning and non-functioning pituitary adenomas, with higher expression in more aggressive tumor subtypes. ErbB2 receptor is detected in all tumor subtypes, particularly in invasive tumors. ErbB tyrosine kinase inhibitors regulate hormonal secretion, cell morphology, and proliferation in lacto-somatotroph tumors, reflecting the emerging application of targeted pituitary therapeutics. Endocrine-Related Cancer (2011) 18 R197-R211

引用

页码：R197 / R211

页数：15

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