Endocrine and metabolic programming during intrauterine development

被引：162
作者：
Fowden, AL [1 ]
Giussani, DA [1 ]
Forhead, AJ [1 ]
机构：
[1] Univ Cambridge, Dept Physiol, Cambridge CB2 3EG, England
来源：
EARLY HUMAN DEVELOPMENT | 2005年 / 81卷 / 09期
关键词：
hypothalamic-pituitary-adrenal axis; glucocorticoids; insulin; insulin resistance; somatotrophic axis; intrauterine programming;
D O I：
10.1016/j.earlhumdev.2005.06.007
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
In humans, low birth weight is associated with an increased risk of metabolic dysfunction in adult life. Many of these metabolic disorders have an endocrine origin and are accompanied by abnormal hormone concentrations. This has led to the hypothesis that adult metabolic disease arises in utero as a result of programming of key endocrine systems during suboptimal intrauterine conditions associated with fetal growth retardation. This review examines the experimental evidence for prenatal endocrine programming with particular emphasis on endocrine axes involved in growth and metabolism, namely, the hypothatamic-pituitary-adrenal axis, the endocrine pancreas and the somatotrophic axis. It also considers how changes in these endocrine systems contribute to the programming of metabolism in later life. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：723 / 734
页数：12
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