Great Expectations for PIP: Phosphoinositides as Regulators of Signaling During Development and Disease

被引：56
作者：
Skwarek, Lara C. [1 ,2 ]
Boulianne, Gabrielle L. [1 ,2 ]
机构：
[1] Hosp Sick Children, Program Dev & Stem Cell Biol, Toronto, ON M5G 1X8, Canada
[2] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A8, Canada
来源：
DEVELOPMENTAL CELL | 2009年 / 16卷 / 01期
基金：
加拿大自然科学与工程研究理事会; 加拿大健康研究院;
关键词：
GAMMA-SECRETASE; PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE; PLASMA-MEMBRANE; NOTCH RECEPTOR; LOWE-SYNDROME; DROSOPHILA-MELANOGASTER; ZEBRAFISH GASTRULATION; DEPENDENT ENDOCYTOSIS; ENDOSOMAL TRAFFICKING; LRP6; PHOSPHORYLATION;
D O I：
10.1016/j.devcel.2008.12.006
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Phosphoinositides function as signaling precursors as well as regulators and scaffolds of signaling molecules required for important cellular processes such as membrane trafficking. Although a picture of the biochemical and cell biological functions of phosphoinositides is emerging, less is known about how these functions impact signaling on a broader scale during development. This review summarizes recent work on the role of phosphoinositides in developmental signaling and in a number of diseases and developmental disorders.
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收藏
页码：12 / 20
页数：9
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