Sudden death during a change in treatment for pulmonary hypertension

被引：3

作者：

Brun, H ^{[1
]}

Holmström, H ^{[1
]}

Thaulow, E ^{[1
]}

机构：

[1] Natl Hosp Norway, Rikshosp, Dept Paediat, Barnehjerteseksjonen, N-0027 Oslo, Norway

来源：

CARDIOLOGY IN THE YOUNG | 2005年 / 15卷 / 02期

关键词：

child; congenital cardiac disease; epoprostenol; sildenafil;

D O I：

10.1017/S1047951105000442

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe an infant with an atrioventricular septal defect and separate valvar orifices for the right and left ventricles, the so-called primum defect, who presented with serious pulmonary hypertension. Treatment with sildenafil was changed to intravenous epoprostenol due to lack of any measurable effects of the initial therapy as shown by echocardiography. The girl died three days after the change in treatment. We suggest that a mismatch between ventilation and perfusion contributed significantly to her death.

引用

页码：223 / 225

页数：3

共 8 条

[1] Atrial septal defect with failure to thrive in infancy: Hidden pulmonary vascular disease? [J].

Andrews, R ;

Tulloh, R ;

Magee, A ;

Anderson, D .

PEDIATRIC CARDIOLOGY, 2002, 23 (05) :528-530

[2] Vasodilator therapy for primary pulmonary hypertension in children [J].

Barst, RJ ;

Maislin, G ;

Fishman, AP .

CIRCULATION, 1999, 99 (09) :1197-1208

[3] EFFECTS OF INFUSION OF PROSTACYCLIN ON ANATOMICAL INTRAPULMONARY RIGHT TO LEFT SHUNT - A USEFUL MODEL OF HUMAN HYPOXIC VASOCONSTRICTION [J].

BUSH, A ;

BUSST, CM ;

KNIGHT, WB ;

SHINEBOURNE, EA .

CLINICAL SCIENCE, 1989, 76 (02) :143-149

[4] Intrapulmonary shunting in primary pulmonary hypertension - An observation in two patients treated with epoprostenol sodium [J].

Castro, PF ;

Bourge, RC ;

McGiffin, DC ;

Benza, RL ;

Fan, P ;

Pinkard, NB ;

McGoon, MD .

CHEST, 1998, 114 (01) :334-336

[5] Flolan infusion interruption: A lethal complication during venous access [J].

Falk, A ;

Lookstein, RA ;

Mitty, HA .

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 2001, 12 (05) :667-668

[6] PULMONARY VASCULAR-DISEASE IN SECUNDUM ATRIAL SEPTAL-DEFECT IN CHILDHOOD [J].

HAWORTH, SG .

AMERICAN JOURNAL OF CARDIOLOGY, 1983, 51 (02) :265-272

[7] Long-term prostacyclin for pulmonary hypertension with associated congenital heart defects [J].

Rosenzweig, EB ;

Kerstein, D ;

Barst, RJ .

CIRCULATION, 1999, 99 (14) :1858-1865

[8] Microatelectasis in patients with secundum atrial septal defect and its relation to pulmonary hypertension [J].

Yamaki, S ;

Abe, A ;

Sato, K ;

Takahashi, T .

JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION, 1997, 61 (05) :384-389

← 1 →