Animal Models of Parkinson's Disease: Are They Useful or Not?

被引：24

作者：

Barker, Roger A. ^{[1
,2
]}

Bjorklund, Anders ^{[3
]}

机构：

[1] Dept Clin Neurosci, Forvie Site, Cambridge CB2 0PY, England

[2] WT MRC Cambridge Stem Cell Inst, Forvie Site, Cambridge CB2 0PY, England

[3] Lund Univ, Wallenberg Neurosci Ctr, Dept Expt Med Sci, S-22184 Lund, Sweden

来源：

JOURNAL OF PARKINSONS DISEASE | 2020年 / 10卷 / 04期

关键词：

Animal models; drug discovery; experimental therapies; alpha-synuclein; dopamine; Lewy bodies; DOPA-INDUCED DYSKINESIA; ALPHA-SYNUCLEIN; FOLLOW-UP; INCIDENT; BRAIN;

D O I：

10.3233/JPD-202200

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The use of animal models in Parkinson's disease research has been controversial in terms of how well they relate to the clinical condition and thus their utility for translating therapies from the lab to the clinic. In this article, two researchers debate this issue with Roger Barker taking the view that such models are not useful and may even be misleading, while Anders Bjorklund defends their use and highlights their value in better understanding and treating this condition.

引用

页码：1335 / 1342

页数：8

共 36 条

[1]

Barbeau A., 1962, MONOAMINES SYSTEME N, P247

[2]

Beach TG, 2009, ACTA NEUROPATHOL, V117, P169, DOI 10.1007/s00401-008-0450-7

[3] OCCURRENCE AND DISTRIBUTION OF DOPAMINE IN BRAIN AND OTHER TISSUES [J].

BERTLER, A ;

ROSENGREN, E .

EXPERIENTIA, 1959, 15 (01) :10-11

[4]

BIRKMAYER W, 1961, Wien Klin Wochenschr, V73, P787

[5] Brain-First versus Gut-First Parkinson's Disease: A Hypothesis [J].

Borghammer, Per ;

Van Den Berge, Nathalie .

JOURNAL OF PARKINSONS DISEASE, 2019, 9 :S281-S295

[6] Neuropathological Staging of Brain Pathology in Sporadic Parkinson's disease: Separating the Wheat from the Chaff [J].

Braak, Heiko ;

Del Tredici, Kelly .

JOURNAL OF PARKINSONS DISEASE, 2017, 7 :S73-S87

[7] Gut-brain axis and the spread of α-synuclein pathology: Vagal highway or dead end? [J].

Breen, David P. ;

Halliday, Glenda M. ;

Lang, Anthony E. .

MOVEMENT DISORDERS, 2019, 34 (03) :307-316

[8] Genetically engineered animal models of Parkinson's disease: From worm to rodent [J].

Breger, Ludivine S. ;

Armentero, Marie T. Fuzzati .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2019, 49 (04) :533-560

[9] What we can learn from iPSC-derived cellular models of Parkinson's disease [J].

Caiazza, Maria Claudia ;

Lang, Charmaine ;

Wade-Martins, Richard .

RECENT ADVANCES IN PARKINSON'S DISEASE, 2020, 252 :3-25

[10] 3,4-DIHYDROXYPHENYLALANINE AND 5-HYDROXYTRYPTOPHAN AS RESERPINE ANTAGONISTS [J].

CARLSSON, A ;

LINDQVIST, M ;

MAGNUSSON, T .

NATURE, 1957, 180 (4596) :1200-1200

← 1 2 3 4 →