Polymorphisms and haplotypes in the multidrug resistance 1 gene (MDR1/ABCB1) and risk of multiple myeloma

被引：34

作者：

Jamroziak, Krzysztof ^{[1
]}

Balcerczak, Ewa ^{[2
]}

Calka, Karolina ^{[2
]}

Piaskowski, Sylwester ^{[3
]}

Urbanska-Rys, Halina ^{[1
]}

Salagacka, Aleksandra ^{[2
]}

Mirowski, Marek ^{[2
]}

Robak, Tadeusz ^{[1
]}

机构：

[1] Med Univ Lodz, Dept Hematol, PL-93513 Lodz, Poland

[2] Med Univ Lodz, Lab Mol Biol & Pharmacogenom, Dept Pharmaceut Biochem, Lodz, Poland

[3] Med Univ Lodz, Dept Mol Pathol & Neuropathol, Lodz, Poland

来源：

LEUKEMIA RESEARCH | 2009年 / 33卷 / 02期

关键词：

P-glycoprotein; MDR1; ABCB1; SNP; Haplotype; Multiple myeloma; Genetic predisposition; MDR1; GENE; SUSCEPTIBILITY;

D O I：

10.1016/j.leukres.2008.06.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MDR1(ABCB1) gene encodes Cor P-glycoprotein (P-gp, MDR1, ABCB1), an ATP-binding cassette superfamily member involved in the transport of xenobiotics. Here, we investigated whether common MDR1 single nucleotide polymorphisms (1236C>T, 2677G>A/T and 3435C>T) affect predisposition to multiple myeloma. Genotyping was performed in 111 myeloma patients and 96 controls by PCR-based assays. Haplotypes were inferred Using PHASE algorithm. We found comparable allele and genotype frequencies among myeloma patients and controls. Moreover, patient and control groups did not differ regarding MDR1 haplotype distribution (p = 0.18). In conclusion, our results do not support major influence of MDR1 variants oil the risk of myeloma in Caucasians. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：332 / 335

页数：4

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