3D Printed Polycaprolactone/Gelatin/Bacterial Cellulose/Hydroxyapatite Composite Scaffold for Bone Tissue Engineering

被引：105

作者：

Cakmak, Abdullah M. ^{[1
,2
]}

Unal, Semra ^{[1
,2
,3
]}

Sahin, Ali ^{[4
]}

Oktar, Faik N. ^{[1
,2
]}

Sengor, Mustafa ^{[2
,5
]}

Ekren, Nazmi ^{[2
,6
]}

Gunduz, Oguzhan ^{[2
,5
]}

Kalaskar, Deepak M. ^{[7
]}

机构：

[1] Marmara Univ, Fac Engn, Dept Bioengn, TR-34722 Istanbul, Turkey

[2] Marmara Univ, Ctr Nanotechnol & Biomat Applicat & Res NBUAM, TR-34722 Istanbul, Turkey

[3] Marmara Univ, Inst Neurol Sci, TR-34722 Istanbul, Turkey

[4] Marmara Univ, Dept Biochem, Sch Med, Genet & Metab Dis Res & Invest Ctr, TR-34722 Istanbul, Turkey

[5] Marmara Univ, Fac Technol, Dept Met & Mat Engn, TR-34722 Istanbul, Turkey

[6] Marmara Univ, Fac Technol, Dept Elect & Elect Engn, TR-34722 Istanbul, Turkey

[7] Royal Free Hosp, UCL Div Surg & Intervent Sci, Campus Rowland,Hill St, London NW3 2PF, England

来源：

POLYMERS | 2020年 / 12卷 / 09期

关键词：

bacterial cellulose; gelatin; polycaprolactone; hydroxyapatite; 3D printing; bone tissue engineering; BACTERIAL CELLULOSE; POLYCAPROLACTONE SCAFFOLDS; GELATIN; FABRICATION; DEPOSITION; FIBERS;

D O I：

10.3390/polym12091962

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Three-dimensional (3D) printing application is a promising method for bone tissue engineering. For enhanced bone tissue regeneration, it is essential to have printable composite materials with appealing properties such as construct porous, mechanical strength, thermal properties, controlled degradation rates, and the presence of bioactive materials. In this study, polycaprolactone (PCL), gelatin (GEL), bacterial cellulose (BC), and different hydroxyapatite (HA) concentrations were used to fabricate a novel PCL/GEL/BC/HA composite scaffold using 3D printing method for bone tissue engineering applications. Pore structure, mechanical, thermal, and chemical analyses were evaluated. 3D scaffolds with an ideal pore size (similar to 300 mu m) for use in bone tissue engineering were generated. The addition of both bacterial cellulose (BC) and hydroxyapatite (HA) into PCL/GEL scaffold increased cell proliferation and attachment. PCL/GEL/BC/HA composite scaffolds provide a potential for bone tissue engineering applications.

引用

页码：1 / 14

页数：14

共 38 条

[1] Green synthesis of bacterial cellulose/bioactive glass nanocomposites: Effect of glass nanoparticles on cellulose yield, biocompatibility and antimicrobial activity [J].