Is cancer gene therapy an empty suit?

被引：47

作者：

Brenner, Malcolm K. ^{[1
,2
,3
,4
]}

Gottschalk, Stephen ^{[1
,2
,3
,5
]}

Leen, Ann M. ^{[1
,2
,3
,5
]}

Vera, Juan F. ^{[1
,2
,4
]}

机构：

[1] Baylor Coll Med, Methodist Hosp, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

[2] Texas Childrens Hosp, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA

[4] Baylor Coll Med, Dept Med, Houston, TX 77030 USA

[5] Baylor Coll Med, Dept Pathol & Immunol, Houston, TX 77030 USA

来源：

LANCET ONCOLOGY | 2013年 / 14卷 / 11期

基金：

美国国家卫生研究院;

关键词：

PLASMID DNA VACCINE; T-CELL-RECEPTORS; DENDRITIC CELLS; CLINICAL-TRIAL; PHASE-I; SUICIDE-GENE; ADOPTIVE IMMUNOTHERAPY; ANTITUMOR-ACTIVITY; DONOR LYMPHOCYTES; MELANOMA PATIENTS;

D O I：

10.1016/S1470-2045(13)70173-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gene therapy as a treatment for cancer is regarded as high in promise, but low in delivery, a deficiency that has become more obvious with ever-increasing reports of the successful correction of monogenic disorders by this approach. We review the commercial and scientific obstacles that have led to these delays and describe how they are progressively being overcome. Recent and striking successes and correspondingly increased commercial involvement suggest that gene transfer could finally become a powerful method for development of safe and effective cancer therapeutic drugs.

引用

页码：E447 / E456

页数：10

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