Anti neutrophil cytoplasmic antibody (ANCA) positive crescentic glomerulonephritis in children. Report of two cases

被引:0
作者
Cavagnaro, F [1 ]
Talesnik, E [1 ]
机构
[1] Pontificia Univ Catolica Chile, Escuela Med, Dept Pediat, Santiago, Chile
关键词
antibodies; ANCA; glomerulonephritis; neutrophil activation; vasculitis;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Anti neutrophil cytoplasmic antibodies are associated to vasculitis and crescentic glomerulonephritis in adults. However, this association has been seldom reported in children. We report two girls aged 12 and 15 years old with ANCA + glomerulonephritis. Both were subjected to a percutaneous kidney biopsy. One girl had to enter a chronic hemodialysis program. The other patient recovered her renal function and after 12 months of treatment with steroids and cyclophosphamide microscopic hematuria and proteinuria persist but with normal kidney function. ANCA should be measured in children with vasculitis and glomerulonephritis.
引用
收藏
页码:970 / 976
页数:7
相关论文
共 14 条
[1]  
Bajema I M, 1999, Curr Opin Rheumatol, V11, P34, DOI 10.1097/00002281-199901000-00006
[2]   RELATIONSHIP BETWEEN DISEASE-ACTIVITY AND ANTINEUTROPHIL CYTOPLASMIC ANTIBODY CONCENTRATION IN LONG-TERM MANAGEMENT OF SYSTEMIC VASCULITIS [J].
DEOLIVIERA, J ;
GASKIN, G ;
DASH, A ;
REES, AJ ;
PUSEY, CD .
AMERICAN JOURNAL OF KIDNEY DISEASES, 1995, 25 (03) :380-389
[3]   SPECTRUM OF DISEASE-ASSOCIATED WITH ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES IN PEDIATRIC-PATIENTS [J].
ELLIS, EN ;
WOOD, EG ;
BERRY, P .
JOURNAL OF PEDIATRICS, 1995, 126 (01) :40-43
[4]  
Falk RJ, 1997, J AM SOC NEPHROL, V8, P314
[5]   ANCA-ASSOCIATED RENAL-DISEASE [J].
FALK, RJ ;
MCCLUSKEY, RT ;
KASSIRER, JP ;
MADIAS, NE ;
NILES, JL ;
KURTIN, P ;
NARAYAN, G ;
LEVEY, AS ;
RABSON, A ;
MADAIO, MP ;
PERRONE, RD ;
VLAKAHOS, DV ;
HARRINGTON, JT .
KIDNEY INTERNATIONAL, 1990, 38 (05) :998-1010
[6]   CLINICAL-FEATURES AND OUTCOME IN PATIENTS WITH GLOMERULONEPHRITIS AND ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES [J].
GANS, ROB ;
KUIZINGA, MC ;
GOLDSCHMEDING, R ;
ASSMANN, K ;
HUYSMANS, FTM ;
GERLAG, PGG ;
DONKER, AJM ;
HOORNTJE, SJ .
NEPHRON, 1993, 64 (02) :182-188
[7]   ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODY-ASSOCIATED DISEASES - A PATHOLOGISTS PERSPECTIVE [J].
JENNETTE, JC .
AMERICAN JOURNAL OF KIDNEY DISEASES, 1991, 18 (02) :164-170
[8]   Effect of diagnostic delay on disease severity and outcome in glomerulonephritis caused by anti-neutrophil cytoplasmic antibodies [J].
Lal, DPSS ;
ODonoghue, DJ ;
Haeney, M .
JOURNAL OF CLINICAL PATHOLOGY, 1996, 49 (11) :942-944
[9]  
Nachman PH, 1996, J AM SOC NEPHROL, V7, P33
[10]  
Noel L H, 1993, Adv Nephrol Necker Hosp, V22, P237